Cited by 151Respiratory Support and MechanismsNosocomial Infections in ICUSepsis Diagnosis and Treatment

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Acute Respiratory Distress Syndrome and Pneumonia: A Comprehensive Review of Clinical Data

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Bauer, T. T., Ewig, S., Rodloff, A. C., Muller, E. E.·2006·Clinical Infectious Diseases

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Abstract

Acute respiratory distress syndrome (ARDS) and pneumonia are closely correlated in the critically ill patient. Whereas ARDS is often complicated by nosocomial pneumonia, pulmonary infection is also the most frequent single cause of ARDS. The prevalence of pneumonia during the course of ARDS seems to be particularly high, but whether persons with ARDS are more susceptible to pneumonia or simply have more risk factors remains unknown because of methodological limitations. Recent research suggests that host factors have a major bearing on the development of ARDS. To date, sepsis seems to be the principal link between pneumonia and ARDS. However, prospective observational data on this supposed sequence are not available. The individual role of specific pathogens for the development of ARDS is difficult to assess, because prospective studies are missing. Respiratory viruses have received particular attention, but this review suggests that infections with coronavirus and avian influenza virus (H5N1) are associated with a high incidence of ARDS.

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Narasaraju, T., Yang, E., Samy, R. P., Ng, H. H., Poh, W. P., Liew, A.-A., Phoon, M. C., van Rooijen, N., & Chow, V. T. K. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.013 · Cited by 918
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460
Acute Lower Respiratory Tract Infection
Mizgerd, J. P. (2008) · New England Journal of Medicine · doi:10.1056/nejmra074111 · Cited by 455
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Zou, Z., Yan, Y., Shu, Y., Gao, R., Sun, Y., Li, X., Ju, X., Liang, Z., Liu, Q., Zhao, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms4594 · Cited by 397
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model
Yan, Y., Zou, Z., Sun, Y., Li, X., Xu, K., Wei, Y., Jin, N., & Jiang, C. (2012) · Cell Research · doi:10.1038/cr.2012.165 · Cited by 353

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Authors: Bauer, T. T., Ewig, S., Rodloff, A. C., & Muller, E. E.
Affiliations: Helios Klinikum Emil von Behring (DE)
Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
Leipzig University (DE)
Corresponding author: Bauer, T. T.
ORCID: Bauer, T. T.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2006-09-15
Volume: 43
Issue: 6
Pages: 748-756
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/506430
PMC: PMC7107989
OpenAlex: W2156551852
Cited by: 151
References: 81
Citations by year: 2026: 3 · 2025: 11 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 19 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 2 · 2014: 10 · 2013: 3 · 2012: 6
FWCI: 0.61
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Clinical Infectious Diseases (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Keywords: acute respiratory distress syndrome, pneumonia, nosocomial pneumonia, sepsis, host factors, respiratory viruses, coronavirus, H5N1 avian influenza, critically ill patients
MeSH terms: Animals, Bacteria, Disease Susceptibility, Humans, Parasites, Pneumonia, Respiratory Distress Syndrome, Respiratory Tract Infections, Risk Factors, Coronavirus, Sepsis, Influenza A Virus, H5N1 Subtype

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Acute Respiratory Distress Syndrome and Pneumonia: A Comprehensive Review of Clinical Data

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