The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
High Rates of Forward Transmission Events after Acute/Early HIV‐1 Infection
Abstract
BACKGROUND: A population-based phylogenetic approach was used to characterize human immunodeficiency virus (HIV)-transmission dynamics in Quebec. METHODS: HIV-1 pol sequences included primary HIV infections (PHIs; <6 months after seroconversion) from the Quebec PHI cohort (1998-2005; n=215) and the provincial genotyping program (2001-2005; n=481). Phylogenetic analysis determined sequence interrelationships among unique PHIs (n=593) and infections from untreated (n=135) and treated (n=660) chronically infected (CI) potential transmitter populations (2001-2005). Clinical features, risk factors, and drug resistance for clustered and nonclustered transmission events were ascertained. RESULTS: Viruses from 49.4% (293/593) of PHIs cosegregated into 75 transmission chains with 2-17 transmissions/cluster. Half of the clusters included 2.7+/-0.8 (mean+/-SD) transmissions, whereas the remainder had 8.8+/-3.5 transmissions. Maximum periods for onward transmission in clusters were 15.2+/-9.5 months. Coclustering of untreated and treated CIs with PHIs were infrequent (6.2% and 4.8%, respectively). The ages, viremia, and risk factors were similar for clustered and nonclustered transmission events. Low prevalence of drug resistance in PHI supported amplified transmissions at early stages. CONCLUSIONS: Early infection accounts for approximately half of onward transmissions in this urban North American study. Therapy at early stages of disease may prevent onward HIV transmission.
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Citations
Cites
Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda.
Wawer, M. J., Gray, R. H., Sewankambo, N. K., Serwadda, D., Li, X., Laeyendecker, O., Kiwanuka, N., Kigozi, G., Kiddugavu, M., Lutalo, T., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/429411 · Cited by 1,258
Cited by
Prospective study of acute HIV-1 infection in adults in East Africa and Thailand.
Robb, M. L., Eller, L. A., Kibuuka, H., Rono, K., Maganga, L., Nitayaphan, S., Kroon, E., Sawe, F. K., Sinei, S., Sriplienchan, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1508952 · Cited by 283
Logan, S. A. E., & MacMahon, E. (2008) · BMJ · doi:10.1136/bmj.39409.673657.ae · Cited by 219
Crowell, T. A., Colby, D. J., Pinyakorn, S., Fletcher, J. L. K., Kroon, E., Schuetz, A., Krebs, S. J., Slike, B. M., Leyre, L., Chomont, N., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix1063 · Cited by 55
Primary HIV infection: clinical presentation, testing, and treatment.
Henn, A., Flateau, C., & Gallien, S. (2017) · Current Infectious Disease Reports · doi:10.1007/s11908-017-0588-3 · Cited by 34
Sanders, E. J., Agutu, C., van der Elst, E., Hassan, A., Gichuru, E., Mugo, P., Farquhar, C., Babigumira, J. B., Goodreau, S. M., Hamilton, D. T., et al. (2022) · HIV Medicine · doi:10.1111/hiv.13157 · Cited by 15
Metadata
- Authors
- Brenner, B. G., Roger, M., Routy, J., Moisi, D., Ntemgwa, M., Matte, C., Baril, J., Thomas, R., Rouleau, D., Bruneau, J., Leblanc, R., Legault, M., Tremblay, C., Charest, H., Wainberg, M. A., & Quebec Primary HIV Infection Study Group
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04
- Volume
- 195
- Issue
- 7
- Pages
- 951-959
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2147547300
- Cited by
- 642
- References
- 1
- FWCI
- 29.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brenner, B. G., Roger, M., Routy, J., Moisi, D., Ntemgwa, M., Matte, C., Baril, J., Thomas, R., Rouleau, D., Bruneau, J., Leblanc, R., Legault, M., Tremblay, C., Charest, H., Wainberg, M. A., & Quebec Primary HIV Infection Study Group. (2007). High Rates of Forward Transmission Events after Acute/Early HIV‐1 Infection. The Journal of Infectious Diseases. https://doi.org/10.1086/512088
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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