The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Human Bocavirus and Acute Wheezing in Children
Open accessAbstract
BACKGROUND: Human bocavirus is a newly discovered parvovirus. It has been detected primarily in children with acute lower respiratory tract infection, but its occurrence, clinical profile, and role as a causative agent of respiratory tract disease are not clear. METHODS: We investigated the presence of human bocavirus by quantitative polymerase chain reaction of nasopharyngeal aspirate specimens and selected serum samples obtained from 259 children (median age, 1.6 years) who had been hospitalized for acute expiratory wheezing. The samples were analyzed for 16 respiratory viruses by polymerase chain reaction, virus culture, antigen detection, and serological assays. RESULTS: At least 1 potential etiologic agent was detected in 95% of children, and >1 agent was detected in 34% of children. Human bocavirus was detected in 49 children (19%). A large proportion of the cases were mixed infections with other viruses, but human bocavirus was the only virus detected in 12 children (5%). High viral loads of human bocavirus were noted mainly in the absence of other viral agents, suggesting a causative role for acute wheezing. In addition, infections that had uncertain clinical relevance and low viral loads were prevalent. Human bocavirus DNA was frequently detected in serum specimens obtained from patients with acute wheezing, suggesting systemic infection. CONCLUSIONS: Human bocavirus is prevalent among children with acute wheezing and can cause systemic infection. Results suggest a model for bocavirus infection in which high viral loads are potentially associated with respiratory symptoms and low viral loads indicate asymptomatic shedding. Therefore, quantitative polymerase chain reaction analysis may be important for additional studies of human bocavirus.
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A newly discovered human pneumovirus isolated from young children with respiratory tract disease
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Self-citationIdentification of a new human coronavirus
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Cloning of a human parvovirus by molecular screening of respiratory tract samples
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Self-citationA previously undescribed coronavirus associated with respiratory disease in humans
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Cited by
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
Tregoning, J. S., & Schwarze, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00032-09 · Cited by 747
Human Bocavirus: Passenger or Pathogen in Acute Respiratory Tract Infections?
Schildgen, O., Müller, A., Allander, T., Mackay, I. M., Völz, S., Kupfer, B., & Simon, A. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00030-07 · Cited by 300
Self-citationEpidemiology and Clinical Associations of Human Parechovirus Respiratory Infections
Harvala, H., Robertson, I., McWilliam Leitch, E. C., Benschop, K., Wolthers, K. C., Templeton, K., & Simmonds, P. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01207-08 · Cited by 213
Emerging respiratory agents: New viruses for old diseases?
Sloots, T. P., Whiley, D. M., Lambert, S. B., & Nissen, M. D. (2008) · Journal of Clinical Virology · doi:10.1016/j.jcv.2008.03.002 · Cited by 124
Metadata
- Authors
- Allander, T., Jartti, T., Gupta, S., Niesters, H. G. M., Lehtinen, P., usterback, R., Vuorinen, T., Waris, M., Bjerkner, A., Tiveljung-Lindell, A., van den Hoogen, B. G., Hyypia, T., & Ruuskanen, O.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-01
- Volume
- 44
- Issue
- 7
- Pages
- 904-910
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2150387021
- Cited by
- 555
- References
- 33
- FWCI
- 42.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Allander, T., Jartti, T., Gupta, S., Niesters, H. G. M., Lehtinen, P., usterback, R., Vuorinen, T., Waris, M., Bjerkner, A., Tiveljung-Lindell, A., van den Hoogen, B. G., Hyypia, T., & Ruuskanen, O. (2007). Human Bocavirus and Acute Wheezing in Children. Clinical Infectious Diseases. https://doi.org/10.1086/512196
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