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Cited by 213Thermal Regulation in MedicineNeuroscience of respiration and sleepNeuropeptides and Animal Physiology

Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs

Blatteis, C.M., Bealer, S.L., Hunter, W.S., Llanos, J.-Q., Ahokas, R.A., Mashburn, T.A.·1983·Brain Research Bulletin
DOI 10.1016/0361-9230(83)90124-7
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Abstract

Endogenous pyrogen (EP), injected systemically or intracerebrally, evokes fever and certain changes in plasma trace metal and glycoprotein levels which are characteristic of the acute-phase reaction. It is generally assumed that EP enters the brain from the blood, although it has not yet been demonstrated that EP crosses the blood-brain barrier (BBB). The possibility that EP might penetrate the brain through the organum vasculosum laminae terminalis (OVLT), which is outside of the BBB and located in close proximity to the medial preoptic region (MPO, the primary site sensitive to locally applied EP), was investigated by making electrolytic lesions (3 mA, 20 sec, anodal) in the anteroventral wall of the third ventricle of guinea pigs (AV3V-X). After 10 days, their febrile and selected acute-phase responses (plasma iron, zinc, copper, and sialic acid levels) to endotoxin (LPS, S. enteritidis, 2 micrograms/kg, IP), which induces EP production by the host, were measured; controls were sham-operated guinea pigs. LPS did not induce in the AV3V-X animals either fever or rises in plasma copper and sialic acid levels; however, as in the controls, it caused hypoferremia and hypozincemia. To exclude damage to the MPO as a cause of these responses, sham and AV3V-X guinea pigs were administered homologous EP intrapreoptically (1 microliter bilaterally). Comparable fevers developed in both groups of animals. Hence, the integrity of the AV3V region including the OVLT seems to be critical for the EP-induced elevations of both body temperature and plasma levels of acute-phase proteins, but not for the fall of plasma iron and zinc levels. It may be that EP passes into the brain through the OVLT.

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Crossref · 10.1016/0361-9230(83)90124-7

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  • Ablation of the vascular organ of the lamina terminalis (a CVO) reduces cytokine-induced fever after injection of lipopolysaccharide (LPS).

    “For example, ablation of the vascular organ of the lamina terminalis (a CVO) reduces cytokine-induced fever after injection of lipopolysaccharide (LPS) (101).”

    From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [101]

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Authors
Blatteis, C. M., Bealer, S. L., Hunter, W. S., Llanos, J.-Q., Ahokas, R. A., & Mashburn, T. A.
Affiliations
University of Tennessee Health Science Center (US)
Venue
Brain Research Bulletin
Publisher
Elsevier BV
Published
1983-11
Volume
11
Issue
5
Pages
519-526
ISSN
0361-9230 (ISSN-L)
DOI
10.1016/0361-9230(83)90124-7
OpenAlex
W2004058553
Cited by
213
References
27
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
8.47
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
endogenous pyrogen, fever, anteroventral third ventricle, organum vasculosum of the lamina terminalis, blood-brain barrier, acute phase response, lipopolysaccharide, plasma iron, zinc, copper, sialic acid, medial preoptic area, electrolytic lesions, guinea pig
MeSH terms
Animals, Behavior, Animal, Body Temperature, Cerebral Ventricles, Colon, Endotoxins, Fever, Guinea Pigs, Male, Salmonella enteritidis

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