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Epidemiology and Clinical Impact of Parainfluenza Virus Infections in Otherwise Healthy Infants and Young Children < 5 Years Old

Open access
Reed, George, Jewett, Paula H., Thompson, Juliette, Tollefson, Sharon, Wright, Peter F.·1997·The Journal of Infectious Diseases

Abstract

Over a 20-year period in a population of otherwise healthy children, respiratory viruses have been cultured from nasal wash specimens from each child with a clinically significant respiratory illness. Since efforts are underway to develop vaccines for prevention of illness due to parainfluenza virus (PIV) type 3, the epidemiologic characteristics of PIVs were reviewed, and the population size necessary to demonstrate vaccine efficacy was estimated. A population of 1429 children was followed through early childhood. PIVs were isolated from 286 samples, 17.4% of positive viral cultures. PIV-3 was the most common: 10% of the children had at least one symptomatic, culture-proven PIV-3 infection. PIV-3 was endemic during the study period, while the other two PIVs, PIV-1 and -2, caused biennial flu epidemics. Only four PIV-related hospitalizations were seen. The efficacy of a PIV-3 vaccine could be demonstrated in a trial of 600 carefully monitored children vaccinated by 3 months and followed to 15 months of age.

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Metadata

Authors
Reed, G., Jewett, P. H., Thompson, J., Tollefson, S., & Wright, P. F.
Venue
The Journal of Infectious Diseases
Published
1997-04
Volume
175
Issue
4
Pages
807-813
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2102010453
Cited by
222
References
1
FWCI
3.22
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Epidemiology and Clinical Impact of Parainfluenza Virus Infections in Otherwise Healthy Infants and Young Children < 5 Years Old. https://app.cochat.ai/papers/10.1086/513975
The paper
Reed, G., Jewett, P. H., Thompson, J., Tollefson, S., & Wright, P. F. (1997). Epidemiology and Clinical Impact of Parainfluenza Virus Infections in Otherwise Healthy Infants and Young Children < 5 Years Old. The Journal of Infectious Diseases. https://doi.org/10.1086/513975

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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