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Cited by 991

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children

Open access
Williams, John V., Harris, Paul A., Tollefson, Sharon J., Halburnt-Rush, Lisa L., Pingsterhaus, Joyce M., Edwards, Kathryn M., Wright, Peter F., Crowe, James E.·2004·New England Journal of Medicine
DOI 10.1056/nejmoa025472
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Abstract

BACKGROUND: We sought to determine the role of human metapneumovirus in lower respiratory tract illness in previously healthy infants and children. METHODS: We tested nasal-wash specimens, obtained over a 25-year period from otherwise healthy children presenting with acute respiratory tract illness, for human metapneumovirus. RESULTS: A viral cause other than human metapneumovirus was determined for 279 of 687 visits for acute lower respiratory tract illness (41 percent) by 463 children in a population of 2009 infants and children prospectively seen from 1976 to 2001. There were 408 visits for lower respiratory tract illness by 321 children for which no cause was identified. Of these 321 children, specimens from 248 were available. Forty-nine of these 248 specimens (20 percent) contained human metapneumovirus RNA or viable virus. Thus, 20 percent of all previously virus-negative lower respiratory tract illnesses were attributable to human metapneumovirus, which means that 12 percent of all lower respiratory tract illnesses in this cohort were most likely due to this virus. The mean age of human metapneumovirus-infected children was 11.6 months, the male:female ratio was 1.8:1, 78 percent of illnesses occurred between December and April, and the hospitalization rate was 2 percent. The virus was associated with bronchiolitis in 59 percent of cases, pneumonia in 8 percent, croup in 18 percent, and an exacerbation of asthma in 14 percent. We also detected human metapneumovirus in 15 percent of samples from 261 patients with upper respiratory tract infection but in only 1 of 86 samples from asymptomatic children. CONCLUSIONS: Human metapneumovirus infection is a leading cause of respiratory tract infection in the first years of life, with a spectrum of disease similar to that of respiratory syncytial virus.

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Metadata

Authors
Williams, J. V., Harris, P. A., Tollefson, S. J., Halburnt-Rush, L. L., Pingsterhaus, J. M., Edwards, K. M., Wright, P. F., & Crowe, J. E.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2004-01-29
Volume
350
Issue
5
Pages
443-450
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa025472
OpenAlex
W2071301221
Cited by
991
References
25
FWCI
55.82
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children. https://app.cochat.ai/papers/10.1056/nejmoa025472
The paper
Williams, J. V., Harris, P. A., Tollefson, S. J., Halburnt-Rush, L. L., Pingsterhaus, J. M., Edwards, K. M., Wright, P. F., & Crowe, J. E. (2004). Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children. New England Journal of Medicine. https://doi.org/10.1056/nejmoa025472

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.