The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Evaluation of Two Live, Cold‐Passaged, Temperature‐Sensitive Respiratory Syncytial Virus Vaccines in Chimpanzees and in Human Adults, Infants, and Children
Open accessAbstract
Two live-attenuated, cold-passaged (cp), temperature-sensitive (ts) candidate vaccines, designated cpts530/1009 and cpts248/955, were attenuated, genetically stable, and immunogenic in chimpanzees and were highly attenuated for human adults. In respiratory syncytial virus (RSV)-seropositive children, cpts530/1009 was more restricted in replication than cpts248/955. In seronegative children, 10(4) pfu of cpts248/955 was insufficiently attenuated, and a high titer of vaccine virus was shed (mean peak titer, 10(4.4) pfu/mL), whereas 10(4) pfu of cpts530/1009 was relatively attenuated and restricted in replication (mean peak titer, 10(2.0) pfu/mL). At a dose of 10(5) pfu, cpts530/1009 was immunogenic in seronegative children (geometric mean titer of RSV neutralizing antibodies, 1:724). Transmission of either vaccine to seronegative placebo recipients occurred at a frequency of 20%-25%. Of importance, vaccine viruses recovered from chimpanzees and humans were ts. In contrast to previous studies, this study indicates that live attenuated RSV vaccines that are immunogenic and phenotypically stable can be developed. Additional studies are being conducted to identify a live RSV vaccine that is slightly more attenuated and less transmissible than cpts530/1009.
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KIM, H. W., CANCHOLA, J. G., BRANDT, C. D., PYLES, G., CHANOCK, R. M., JENSEN, K., & PARROTT, R. H. (1969) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a120955 · Cited by 1,981
Groothuis, J. R., Simoes, E., Levin, M. J., Hall, C. B., Long, C. E., Rodriguez, W. J., Arrobio, J., Meissner, H. C., Fulton, D. R., Welliver, R. C., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311183292102 · Cited by 744
Cited by
Respiratory Syncytial Virus Infection in Adults
Falsey, A. R., & Walsh, E. E. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.3.371 · Cited by 438
Karron, R. A., Buonagurio, D. A., Georgiu, A. F., Whitehead, S. S., Adamus, J. E., Clements-Mann, M. L., Harris, D. O., Randolph, V. B., Udem, S. A., Murphy, B. R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13961 · Cited by 420
Self-citationKarron, R. A., Wright, P. F., Belshe, R. B., Thumar, B., Casey, R., Newman, F., Polack, F. P., Randolph, V. B., Deatly, A., Hackell, J., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/427813 · Cited by 287
Self-citationRespiratory syncytial and other virus infections in persons with chronic cardiopulmonary disease
WALSH, E. E., FALSEY, A. R., & HENNESSEY, P. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.3.9901004 · Cited by 187
Respiratory syncytial virus vaccine development
Crowe, J. E. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00287-0 · Cited by 70
Metadata
- Authors
- Karron, R. A., Wright, P. F., Crowe, Jr., Clements‐Mann, M. L., Thompson, J., Makhene, M., Casey, R., & Murphy, B. R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-12
- Volume
- 176
- Issue
- 6
- Pages
- 1428-1436
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2122557423
- Cited by
- 208
- References
- 2
- FWCI
- 14.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Karron, R. A., Wright, P. F., Crowe, Jr., Clements‐Mann, M. L., Thompson, J., Makhene, M., Casey, R., & Murphy, B. R. (1997). Evaluation of Two Live, Cold‐Passaged, Temperature‐Sensitive Respiratory Syncytial Virus Vaccines in Chimpanzees and in Human Adults, Infants, and Children. The Journal of Infectious Diseases. https://doi.org/10.1086/514138
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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