The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Evidence of Systemic Dissemination of Chlamydia pneumoniae via Macrophages in the Mouse
Abstract
Chlamydia pneumoniae has been postulated to cause systemic disease by infection of monocytes/macrophages and spread via the blood or lymphatics. To investigate how C. pneumoniae disseminates, the ability of the organism to infect murine macrophages in vivo and whether infection can be transferred via macrophages were determined. C. pneumoniae was detected by direct plating, isolation, and polymerase chain reaction in alveolar macrophages from intranasally inoculated mice and peritoneal macrophages from intraperitoneally inoculated mice. C. pneumoniae were also detected in peripheral blood mononuclear cells, but not plasma, of intranasally and intraperitoneally inoculated mice. When alveolar or peritoneal macrophages were adoptively transferred by intraperitoneal injection from infected to uninfected mice, C. pneumoniae DNA was detected by polymerase chain reaction in lung, thymus, spleen, and/or abdominal lymph nodes. These results demonstrate the ability of C. pneumoniae to infect macrophages in vivo and to disseminate systemically via infected macrophages by hematogenous and lymphatic routes.
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Cites
Kuo, C. C., Jackson, L. A., Campbell, L. A., & Grayston, J. T. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.451 · Cited by 819
Self-citationGaydos, C. A., Summersgill, J. T., Sahney, N. N., Ramirez, J. A., & Quinn, T. C. (1996) · Infection and Immunity · doi:10.1128/iai.64.5.1614-1620.1996 · Cited by 442
Patterns of lymphatic drainage in the adult laboratory rat.
Tilney, N. L. (1971) · Europe PMC (PubMed Central) · Cited by 400
Detection of Chlamydia pneumoniae by polymerase chain reaction
Campbell, L. A., Perez Melgosa, M., Hamilton, D. J., Kuo, C. C., & Grayston, J. T. (1992) · Journal of Clinical Microbiology · doi:10.1128/jcm.30.2.434-439.1992 · Cited by 258
Self-citationMurine Models of Chlamydia pneumoniae Infection and Atherosclerosis
Moazed, T. C., Kuo, C., Grayston, J. T., & Campbell, L. A. (1997) · The Journal of Infectious Diseases · doi:10.1086/513986 · Cited by 249
Self-citationIn vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae
Godzik, K. L., O'Brien, E. R., Wang, S. K., & Kuo, C. C. (1995) · Journal of Clinical Microbiology · doi:10.1128/jcm.33.9.2411-2414.1995 · Cited by 189
Self-citationA Sensitive Cell Line, HL Cells, for Isolation and Propagation of Chlamydia pneumoniae Strain TWAR
Kuo, C., & Grayston, J. T. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/162.3.755 · Cited by 139
Self-citationReactivation of Chlamydia pneumoniae Lung Infection in Mice by Cortisone
Malinverni, R., Kuo, C.-C., Campbell, L. A., & Grayston, J. T. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/172.2.593 · Cited by 100
Self-citationChlamydia pneumoniae (TWAR) infections in children
Grayston, J. T. (1994) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199408000-00001 · Cited by 98
Self-citationExperimental rabbit models of Chlamydia pneumoniae infection.
Moazed, T. C., Kuo, C. C., Patton, D. L., Grayston, J. T., & Campbell, L. A. (1996) · Europe PMC (PubMed Central) · Cited by 86
Self-citation
Cited by
Hu, H., Pierce, G. N., & Zhong, G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4582 · Cited by 297
Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279
Chlamydia pneumoniae — an infectious risk factor for atherosclerosis?
Campbell, L. A., & Kuo, C.-C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro796 · Cited by 277
Self-citationInfectious Agents Are Not Necessary for Murine Atherogenesis
Wright, S. D., Burton, C., Hernandez, M., Hassing, H., Montenegro, J., Mundt, S., Patel, S., Card, D. J., Hermanowski-Vosatka, A., Bergstrom, J. D., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1437 · Cited by 176
Santangelo, R., Zoellner, H., Sorrell, T., Wilson, C., Donald, C., Djordjevic, J., Shounan, Y., & Wright, L. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2229-2239.2004 · Cited by 169
Metadata
- Authors
- Moazed, T. C., Kuo, C., Grayston, J. T., & Campbell, L. A.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05
- Volume
- 177
- Issue
- 5
- Pages
- 1322-1325
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2167839862
- Cited by
- 264
- References
- 11
- FWCI
- 19.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence of Systemic Dissemination of Chlamydia pneumoniae via Macrophages in the Mouse. https://app.cochat.ai/papers/10.1086/515280
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- Moazed, T. C., Kuo, C., Grayston, J. T., & Campbell, L. A. (1998). Evidence of Systemic Dissemination of Chlamydia pneumoniae via Macrophages in the Mouse. The Journal of Infectious Diseases. https://doi.org/10.1086/515280
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
