The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae
Open accessAbstract
Epidemiological investigations have linked Chlamydia pneumoniae infection to atherosclerosis. It is not clear, however, whether C. pneumoniae infection plays a causal role in the development of atherosclerosis. Mice with low-density lipoprotein receptor deficiency were induced to develop atherosclerotic lesions in aorta with a cholesterol-enriched diet that increased serum cholesterol by two- to threefold. Using this mouse model, we found that the chlamydial infection alone with either the C. pneumoniae AR39 or the C. trachomatis MoPn strain failed to induce any significant atherosclerotic lesions in aorta over a period of nine months. However, in the presence of a high-cholesterol diet, infection with the C. pneumoniae AR39 strain significantly exacerbated the hypercholesterolemia-induced atherosclerosis, demonstrating that a hypercholesterolemic condition is required for the C. pneumoniae to aggravate the development of atherosclerosis. Although both AR39 and MoPn antigens were detected in aorta of mice infected with the corresponding strains, only mice infected with the C. pneumoniae strain AR39 displayed enhanced atherosclerotic lesions, suggesting that the C. pneumoniae species may possess a unique atherogenic property. This study may provide a model for further understanding the mechanisms of C. pneumoniae atherogenesis and evaluating chlamydial intervention strategies for preventing the advancement of atherosclerotic lesions enhanced by C. pneumoniae infection.
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Chlamydia pneumoniae (TWAR) in Atherosclerosis of the Carotid Artery
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Cited by
Inflammation, Atherosclerosis, and Coronary Artery Disease
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INFLAMMATION AND ATHEROSCLEROSIS
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Metadata
- Authors
- Hu, H., Pierce, G. N., & Zhong, G.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-03-01
- Volume
- 103
- Issue
- 5
- Pages
- 747-753
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1966187634
- Cited by
- 297
- References
- 22
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
