The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Chlamydia trachomatis Persistence In Vitro: An Overview
Open accessAbstract
Chlamydiae growing in target mucosal human epithelial cells in vitro can transition from their normal developmental cycle progression, alternating between infectious but metabolically inactive elementary bodies to metabolically active but noninfectious reticulate bodies (RBs) and back to elementary bodies, into a state of persistence. Persistence in vitro is defined as viable but noncultivable chlamydiae involving morphologically enlarged, aberrant, and nondividing RBs. The condition is reversible, yielding infectious elementary bodies after removal of the inducers, including penicillin, interferon-gamma, iron or nutrient starvation, concomitant herpes infection, or maturation of the host cell into its physiologically differentiated state. All aberrant RB phenotypes are not the same, owing to differing up- or down-regulated chlamydial gene sets and subsequent host responses. Although all persistence-inducing conditions exist in vivo, key questions include (1) whether or not aberrant chlamydial RBs occur in vivo during the alternating acute-silent chronic-acute chlamydial infection scenario that exists in infected patients and animals and (2) whether such aberrant RBs can contribute to prolonged, chronic inflammation, fibrosis, and scarring.
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Cites
The chlamydial developmental cycle: Figure 1
AbdelRahman, Y. M., & Belland, R. J. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.03.002 · Cited by 631
Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis
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Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis
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Beatty, W. L., Byrne, G. I., & Morrison, R. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.3998 · Cited by 466
Chlamydial Persistence: beyond the Biphasic Paradigm
Hogan, R. J., Mathews, S. A., Mukhopadhyay, S., Summersgill, J. T., & Timms, P. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.1843-1855.2004 · Cited by 461
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Pathogenesis of Genital Tract Disease Due to Chlamydia trachomatis
Darville, T., & Hiltke, T. J. (2010) · The Journal of Infectious Diseases · doi:10.1086/652397 · Cited by 334
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Chlamydia pneumoniae Infection in Circulating Human Monocytes Is Refractory to Antibiotic Treatment
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Cited by
Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
(2019) · doi:10.7554/elife.42295 · Cited by 31
Metadata
- Authors
- Wyrick, P. B.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-15
- Volume
- 201
- Issue
- S2
- Pages
- 88-95
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2145528532
- Cited by
- 257
- References
- 27
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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