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Chlamydial Persistence: beyond the Biphasic Paradigm
Open accessAbstract
The chlamydiae are an evolutionarily distinct group of eubacteria sharing an obligate intracellular lifestyle and a unique developmental cycle that has been well characterized under favorable cell culture conditions. This cycle begins when infectious, metabolically inert elementary bodies (EB) attach to and stimulate uptake by the host cell. The internalized EB remains within a host-derived vacuole, termed an inclusion, and differentiates to a larger, metabolically active reticulate body (RB). The RB multiplies by binary fission, and after 8 to 12 rounds of multiplication, the RB differentiate to EB asynchronously (78). At 30 to 84 h postinfection (PI), depending primarily on the infecting species, EB progeny are released from the host cell to initiate another cycle (78, 122).
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Cites
Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain
Balin, B. J., Gérard, H. C., Arking, E. J., Appelt, D. M., Branigan, P. J., Abrams, J. T., Whittum-Hudson, J. A., & Hudson, A. P. (1998) · Medical Microbiology and Immunology · doi:10.1007/s004300050071 · Cited by 506
Chlamydia pneumoniae Infection in Human Monocytes
Airenne, S., Surcel, H.-M., Alakärppä, H., Laitinen, K., Paavonen, J., Saikku, P., & Laurila, A. (1999) · Infection and Immunity · doi:10.1128/iai.67.3.1445-1449.1999 · Cited by 138
Cited by
The chlamydial developmental cycle: Figure 1
AbdelRahman, Y. M., & Belland, R. J. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.03.002 · Cited by 631
Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279
Chlamydia trachomatis Persistence In Vitro: An Overview
Wyrick, P. B. (2010) · The Journal of Infectious Diseases · doi:10.1086/652394 · Cited by 257
Targeted delivery of antibiotics to intracellular chlamydial infections using PLGA nanoparticles
Toti, U. S., Guru, B. R., Hali, M., McPharlin, C. M., Wykes, S. M., Panyam, J., & Whittum-Hudson, J. A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.038 · Cited by 143
The end of the road for the tryptophan depletion concept in pregnancy and infection
Badawy, A. A.-B., Namboodiri, A. M. A., & Moffett, J. R. (2016) · Clinical Science · doi:10.1042/cs20160153 · Cited by 92
Metadata
- Authors
- Hogan, R. J., Mathews, S. A., Mukhopadhyay, S., Summersgill, J. T., & Timms, P.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2004-04
- Volume
- 72
- Issue
- 4
- Pages
- 1843-1855
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2097889231
- Cited by
- 461
- References
- 2
- FWCI
- 23.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Hogan, R. J., Mathews, S. A., Mukhopadhyay, S., Summersgill, J. T., & Timms, P. (2004). Chlamydial Persistence: beyond the Biphasic Paradigm. Infection and Immunity. https://doi.org/10.1128/iai.72.4.1843-1855.2004
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