The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Serological Correlate of Protection against Norovirus‐Induced Gastroenteritis
Open accessAbstract
BACKGROUND: Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection. We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure. METHODS: We developed an HBGA blocking assay to examine the ability of human serum to block the interaction of NV viruslike particles with H type 1 and H type 3 glycans. Serum samples from persons who were experimentally challenged with NV were evaluated. RESULTS: There was a high correlation between the H type 1 and H type 3 synthetic glycan assays (r = 0.977; P < .001); the H type 1 assay had higher quantitative sensitivity (P < .001). Among 18 infected secretor-positive individuals, blocking titers peaked by day 28 after challenge and were higher for individuals who did not develop gastroenteritis than for those who developed gastroenteritis on days 0, 14, 28, and 180 (P < .05 for each). In addition, 6 of 6 subjects without gastroenteritis had measurable prechallenge blocking titers (>25), compared with 2 of 12 subjects with gastroenteritis (P = .002). CONCLUSIONS: Blocking antibodies correlate with protection against clinical NV gastroenteritis. This knowledge will help guide the evaluation of new vaccine strategies and the elucidation of the nature of immunity to the virus. Trial registration. ClinicalTrials.gov identifier: NCT00138476.
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Cites
Food-Related Illness and Death in the United States
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Human susceptibility and resistance to Norwalk virus infection
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Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein
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Self-citationNorwalk Virus Shedding after Experimental Human Infection
Atmar, R. L., Opekun, A. R., Gilger, M. A., Estes, M. K., Crawford, S. E., Neill, F. H., & Graham, D. Y. (2008) · Emerging Infectious Diseases · doi:10.3201/eid1410.080117 · Cited by 760
Self-citationMarionneau, S., Ruvoën, N., Le Moullac–Vaidye, B., Clement, M., Cailleau–Thomas, A., Ruiz–Palacois, G., Huang, P., Jiang, X., & Le Pendu, J. (2002) · Gastroenterology · doi:10.1053/gast.2002.33661 · Cited by 526
Norwalk Virus Infection and Disease Is Associated with ABO Histo–Blood Group Type
Hutson, A. M., Atmar, R. L., Graham, D. Y., & Estes, M. K. (2002) · The Journal of Infectious Diseases · doi:10.1086/339883 · Cited by 487
Self-citationClinical Immunity in Acute Gastroenteritis Caused by Norwalk Agent
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Norwalk Virus Infection of Volunteers: New Insights Based on Improved Assays
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Norovirus and its histo-blood group antigen receptors: an answer to a historical puzzle
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Cited by
Replication of human noroviruses in stem cell–derived human enteroids
Ettayebi, K., Crawford, S. E., Murakami, K., Broughman, J. R., Karandikar, U., Tenge, V. R., Neill, F. H., Blutt, S. E., Zeng, X.-L., Qu, L., et al. (2016) · Science · doi:10.1126/science.aaf5211 · Cited by 1,305
Self-citationBányai, K., Estes, M. K., Martella, V., & Parashar, U. D. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31128-0 · Cited by 445
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Metadata
- Authors
- Reeck, A., Kavanagh, O., Estes, M. K., Opekun, A. R., Gilger, M. A., Graham, D. Y., & Atmar, R. L.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10-15
- Volume
- 202
- Issue
- 8
- Pages
- 1212-1218
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2015411778
- Cited by
- 278
- References
- 30
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Reeck, A., Kavanagh, O., Estes, M. K., Opekun, A. R., Gilger, M. A., Graham, D. Y., & Atmar, R. L. (2010). Serological Correlate of Protection against Norovirus‐Induced Gastroenteritis. The Journal of Infectious Diseases. https://doi.org/10.1086/656364
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