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Cited by 278

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Serological Correlate of Protection against Norovirus‐Induced Gastroenteritis

Open access
Reeck, Amanda, Kavanagh, Owen, Estes, Mary K., Opekun, Antone R., Gilger, Mark A., Graham, David Y., Atmar, Robert L.·2010·The Journal of Infectious Diseases
DOI 10.1086/656364
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Abstract

BACKGROUND: Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection. We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure. METHODS: We developed an HBGA blocking assay to examine the ability of human serum to block the interaction of NV viruslike particles with H type 1 and H type 3 glycans. Serum samples from persons who were experimentally challenged with NV were evaluated. RESULTS: There was a high correlation between the H type 1 and H type 3 synthetic glycan assays (r = 0.977; P < .001); the H type 1 assay had higher quantitative sensitivity (P < .001). Among 18 infected secretor-positive individuals, blocking titers peaked by day 28 after challenge and were higher for individuals who did not develop gastroenteritis than for those who developed gastroenteritis on days 0, 14, 28, and 180 (P < .05 for each). In addition, 6 of 6 subjects without gastroenteritis had measurable prechallenge blocking titers (>25), compared with 2 of 12 subjects with gastroenteritis (P = .002). CONCLUSIONS: Blocking antibodies correlate with protection against clinical NV gastroenteritis. This knowledge will help guide the evaluation of new vaccine strategies and the elucidation of the nature of immunity to the virus. Trial registration. ClinicalTrials.gov identifier: NCT00138476.

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Metadata

Authors
Reeck, A., Kavanagh, O., Estes, M. K., Opekun, A. R., Gilger, M. A., Graham, D. Y., & Atmar, R. L.
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2010-10-15
Volume
202
Issue
8
Pages
1212-1218
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/656364
OpenAlex
W2015411778
Cited by
278
References
30
FWCI
8.45
Type
journal article
Language
en
Open access
bronze

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