Characterization of optical parameters with a human forearm at the region from 1.15 to 1.52 µm using diffuse reflectance measurements
Open accessAbstract
Time- and space-resolved diffuse reflectance measurements were used to identify the optical parameters, the reduced scattering and absorption coefficients, of bulk living tissue in the region from 1.15 to 1.52 microm. Although in this region the detector was limited in its temporal resolution, we applied a peak-time shift analysis successfully to determine these coefficients in a human forearm, and then determined the absorption spectrum by space-resolved diffuse reflectance measurements. The absorption spectrum of a water content of 52% determined by magnetic resonance imaging experiments is in good agreement with the absorption coefficient obtained by optical measurements. Moreover, magnetic resonance imaging measurements suggest that the deviation of the absorption coefficients from the water spectrum in the strong water absorption band is caused by the heterogeneity of water distribution in tissue: the low content of water in the skin. These findings indicate that this optical method is potentially applicable to the non-invasive measurement of water in tissue, especially in a region lower than about 1.3-1.35 microm, which may be useful in monitoring oedema and tissue swelling.
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Penetration depth is less than 1 mm in the 1400 nm water absorption band.
“They found that the penetration depth is less than 1 mm in the 1400 nm water absorption band”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [55]
Penetration depth of optical measurements changes significantly at wavelengths corresponding with strong water absorption at longer wavelengths.
“Nishimura et al.55 described how the penetration depth of optical measurements changes significantly at wavelengths corresponding with strong water absorption at longer wavelengths.”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [55]
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- Authors
- Nishimura, G., Kida, I., & Tamura, M.
- Affiliations
- Hokkaido University (JP)
- Venue
- Physics in Medicine and Biology
- Publisher
- IOP Publishing
- Published
- 2006-05-24
- Volume
- 51
- Issue
- 11
- Pages
- 2997-3011
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- OpenAlex
- W2020238249
- Cited by
- 20
- References
- 35
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Physics in Medicine and Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hamamatsu Photonics K.K.
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Keywords
- diffuse reflectance, reduced scattering coefficient, absorption coefficient, forearm, near-infrared spectroscopy, absorption spectra, tissue water content, water absorption bands, tissue heterogeneity
- MeSH terms
- Edema, Forearm, Humans, Magnetic Resonance Imaging, Radiography, Refractometry, Scattering, Radiation, Spectrum Analysis, Tissue Distribution, Water, Soft Tissue Injuries, Optics and Photonics
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