The DOI matches its Crossref record; 176 of the 176 references it cites were found in a registry or an index.
Tensegrity, cellular biophysics, and the mechanics of living systems
Open accessAbstract
The recent convergence between physics and biology has led many physicists to enter the fields of cell and developmental biology. One of the most exciting areas of interest has been the emerging field of mechanobiology that centers on how cells control their mechanical properties, and how physical forces regulate cellular biochemical responses, a process that is known as mechanotransduction. In this article, we review the central role that tensegrity (tensional integrity) architecture, which depends on tensile prestress for its mechanical stability, plays in biology. We describe how tensional prestress is a critical governor of cell mechanics and function, and how use of tensegrity by cells contributes to mechanotransduction. Theoretical tensegrity models are also described that predict both quantitative and qualitative behaviors of living cells, and these theoretical descriptions are placed in context of other physical models of the cell. In addition, we describe how tensegrity is used at multiple size scales in the hierarchy of life—from individual molecules to whole living organisms—to both stabilize three-dimensional form and to channel forces from the macroscale to the nanoscale, thereby facilitating mechanochemical conversion at the molecular level.
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Cites
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“Much of the subsequent research in this area has focused on the role to tension applied on integrins at focal adhesions (Vogel and Sheetz 2006).”
Background
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Musah, S., Mammoto, A., Ferrante, T. C., Jeanty, S. S. F., Hirano-Kobayashi, M., Mammoto, T., Roberts, K., Chung, S., Novak, R., Ingram, M., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0069 · Cited by 538
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Metadata
- Authors
- Ingber, D. E., Wang, N., & Stamenović, D.
- Venue
- Reports on Progress in Physics
- Publisher
- IOP Publishing
- Published
- 2014-04-01
- Volume
- 77
- Issue
- 4
- Pages
- 046603
- ISSN
- 0034-4885 (ISSN-L)
- 1361-6633
- OpenAlex
- W1978514943
- Cited by
- 485
- References
- 176
- FWCI
- 16.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Ingber, D. E., Wang, N., & Stamenović, D. (2014). Tensegrity, cellular biophysics, and the mechanics of living systems. Reports on Progress in Physics. https://doi.org/10.1088/0034-4885/77/4/046603
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
