The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Polymeric worm micelles as nano-carriers for drug delivery
Abstract
Nanoscale carriers of active compounds, especially drugs, need not be spherical in shape. Worm micelles as blends of degradable polylactic acid (PLA) and inert block copolymer amphiphiles were prepared for controlled release and initial study of carrier transport through nano-porous media. The loading capacity of a typical hydrophobic drug, Triamterene, and the release of hydrophobic dyes were evaluated together with morphological changes of the micelles. Degradation of PLA by hydrolysis led to the self-shortening of worms and a clear transition towards spherical micelles, correlating with the release of hydrophobic dyes. Perhaps equally important for application is the flexibility of worm micelles, which we show allows them to penetrate nanoporous gels where 100 nm sized vesicles cannot enter. Such gels have served as tissue models, and so the results here collectively suggest a new class of hydrophobic drug nano-carriers that are capable of tissue permeation as well as controlled release.
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“Polylactic acid has good biocompatibility and degradability, which has led to its being widely used in the medical field [40,70,71,72].”
From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [70]
Citations
Cites
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Items 201–207 of 207
Emergent Hybrid Nanostructures Based on Non‐Equilibrium Block Copolymer Self‐Assembly
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Delivery of Worm-like Drug Carriers in Stenotic Mrcovessels: A Simulation Study
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Dynamics of amphiphilic PEG–PDMS–PEG triblock copolymer assemblies
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Biological Treatments (Antibodies)
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Metadata
- Authors
- Kim, Y., Dalhaimer, P., Christian, D. A., & Discher, D. E.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Dalhaimer, Paul
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2005-05-18
- Volume
- 16
- Issue
- 7
- Pages
- S484-S491
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W2127597183
- Cited by
- 207
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 14 · 2012: 12
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
- Keywords
- wormlike micelles, polymeric micelles, drug delivery, polylactic acid, amphiphilic block copolymers, controlled release, triamterene, hydrophobic drug loading, hydrolytic degradation, micelle morphology
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