The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles
Open accessAbstract
Nanoparticles are increasingly being recognized for their potential utility in biological applications including nanomedicine. Here we examine the response of normal human cells to ZnO nanoparticles under different signaling environments and compare it to the response of cancerous cells. ZnO nanoparticles exhibit a strong preferential ability to kill cancerous T cells ( approximately 28-35x) compared to normal cells. Interestingly, the activation state of the cell contributes toward nanoparticle toxicity, as resting T cells display a relative resistance while cells stimulated through the T cell receptor and CD28 costimulatory pathway show greater toxicity in direct relation to the level of activation. Mechanisms of toxicity appear to involve the generation of reactive oxygen species, with cancerous T cells producing higher inducible levels than normal T cells. In addition, nanoparticles were found to induce apoptosis and the inhibition of reactive oxygen species was found to be protective against nanoparticle induced cell death. The novel findings of cell selective toxicity, towards potential disease causing cells, indicate a potential utility of ZnO nanoparticles in the treatment of cancer and/or autoimmunity.
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Cites
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930
Xia, T., Kovochich, M., Brant, J., Hotze, M., Sempf, J., Oberley, T., Sioutas, C., Yeh, J. I., Wiesner, M. R., & Nel, A. E. (2006) · Nano Letters · doi:10.1021/nl061025k · Cited by 1,918
The CD40 Antigen and Its Ligand
Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J., van Kooten, C., Liu, Y. J., Rousset, F., & Saeland, S. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.881 · Cited by 1,263
Mechanisms of Cell Death in Oxidative Stress
Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., & Choi, A. M. K. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.9.49 · Cited by 1,261
Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems
Reddy, K. M., Feris, K., Bell, J., Wingett, D. G., Hanley, C., & Punnoose, A. (2007) · Applied Physics Letters · doi:10.1063/1.2742324 · Cited by 979
Self-citationNanotechnology applications in cancer
Nie, S., Xing, Y., Kim, G. J., & Simons, J. W. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.152025 · Cited by 952
Long, T. C., Saleh, N., Tilton, R. D., Lowry, G. V., & Veronesi, B. (2006) · Environmental Science & Technology · doi:10.1021/es060589n · Cited by 870
Burns, A., Ow, H., & Wiesner, U. (2006) · Chem. Soc. Rev. · doi:10.1039/b600562b · Cited by 849
Current Protocols in Immunology
(2001) · John Wiley & Sons, Inc. eBooks · doi:10.1002/0471142735 · Cited by 785
Cited by
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism
Król, A., Pomastowski, P., Rafińska, K., Railean-Plugaru, V., & Buszewski, B. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.07.033 · Cited by 731
Zinc Oxide Nanoparticles for Revolutionizing Agriculture: Synthesis and Applications
Sabir, S., Arshad, M., & Chaudhari, S. K. (2014) · The Scientific World Journal · doi:10.1155/2014/925494 · Cited by 721
Recent advances in ZnO nanostructures and thin films for biosensor applications: Review
Arya, S. K., Saha, S., Ramirez-Vick, J. E., Gupta, V., Bhansali, S., & Singh, S. P. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.05.048 · Cited by 579
Analytical methods to assess nanoparticle toxicity
Marquis, B. J., Love, S. A., Braun, K. L., & Haynes, C. L. (2009) · The Analyst · doi:10.1039/b818082b · Cited by 406
Metadata
- Authors
- Hanley, C., Layne, J., Punnoose, A., Reddy, K. M., Coombs, I., Coombs, A., Feris, K., & Wingett, D.
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2008-06-10
- Volume
- 19
- Issue
- 29
- Pages
- 295103
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W3142110808
- Cited by
- 656
- References
- 25
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- green
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