Cited by 267Nanoparticles: synthesis and applicationsCharacterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug Delivery

Biocompatibility of Fe3O4nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells

Ankamwar, B, Lai, T C, Huang, J H, Liu, R S, Hsiao, M, Chen, C H, Hwu, Y K·2010·Nanotechnology

Abstract

In order to reveal the biocompatibility of Fe(3)O(4) nanoparticles and bipolar surfactant tetramethylammonium 11-aminoundecanoate cytotoxicity tests were performed as a function of concentration from low (0.1 microg ml(-1)) to higher concentration (100 microg ml(-1)) using various human glia, human breast cancer and normal cell lines. Cytotoxicity tests for human glia (D54MG, G9T, SF126, U87, U251, U373), human breast cancer (MB157, SKBR3, T47D) and normal (H184B5F5/M10, WI-38, SVGp12) cell lines exhibited almost nontoxicity and reveal biocompatibility of Fe(3)O(4) nanoparticles in the concentration range of 0.1-10 microg ml(-1), while accountable cytotoxicity can be seen at 100 microg ml(-1). The results of our studies suggest that Fe(3)O(4) nanoparticles coated with bipolar surfactant tetramethylammonium 11-aminoundecanoate are biocompatible and promising for bio-applications such as drug delivery, magnetic resonance imaging and magnetic hyperthermia.

Integrity signals

Registry

Crossref · 10.1088/0957-4484/21/7/075102

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In vitro, upon prolonged incubation, surface-coated SPION are typically nontoxic at iron concentrations up to 10 μg/ml, while slight cytotoxicity is seen at 100 μg/ml.

    “In vitro, upon prolonged incubation, surface-coated SPION are typically nontoxic at iron concentration up to and 10 μg/ml, while slight cytotoxicity is seen at 100 μg/ml.”
  • SPION toxicity depends on dosing, exposure time, nature of the coating material, hydrodynamic diameter of the particle and SPION-protein interactions.

    “In general, SPION toxicity depends on a variety of factors, including - besides dosing and exposure time - also the nature of the coating material, the hydrodynamic diameter of the particle and SPION-protein interactions [119–122].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ankamwar, B., Lai, T. C., Huang, J. H., Liu, R. S., Hsiao, M., Chen, C. H., & Hwu, Y. K.
Affiliations
  • National Taiwan University (TW)
  • Genomics Research Center, Academia Sinica (TW)
  • Institute of Physics, Academia Sinica (TW)
Corresponding author
Liu, R S
Venue
Nanotechnology
Published
2010-01-21
Volume
21
Issue
7
Pages
075102
ISSN
  • 0957-4484 (ISSN-L)
  • 1361-6528
OpenAlex
W2073884591
Cited by
267
References
42
Citations by year
2026: 1 · 2025: 14 · 2024: 15 · 2023: 15 · 2022: 17 · 2021: 29 · 2020: 17 · 2019: 23 · 2018: 21 · 2017: 18 · 2016: 20 · 2015: 20 · 2014: 21 · 2013: 16 · 2012: 11
FWCI
5.65
Type
journal article
Language
en
Open access
closed
Locations
  • Nanotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Science Council
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
Fe3O4 nanoparticles, magnetic nanoparticles, biocompatibility, cytotoxicity, glial cells, breast cancer cells, surfactant coating, drug delivery, magnetic hyperthermia, magnetic resonance imaging
MeSH terms
Amino Acids, Quaternary Ammonium Compounds, Biocompatible Materials, Breast, Breast Neoplasms, Cell Line, Cell Survival, Female, Ferric Compounds, Humans, Materials Testing, Microscopy, Neuroglia, Surface-Active Agents, Cell Line, Tumor, Metal Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review