Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T 1 - and T 2 -weighted magnetic resonance imaging

Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications

Caravan, P. D., Ellison, J. J., McMurry, T. J., & Lauffer, R. B. (1999) · Chemical Reviews · doi:10.1021/cr980440x · Cited by 4,571

Magnetic nanoparticles in MR imaging and drug delivery

Sun, C., Lee, J. S. H., & Zhang, M. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.018 · Cited by 2,642

The preparation of magnetic nanoparticles for applications in biomedicine

Tartaj, P., Morales, M. P., Veintemillas-Verdaguer, S., o, T. G. L.-C., & Serna, C. J. (2003) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/36/13/202 · Cited by 1,963

Iron oxide MR contrast agents for molecular and cellular imaging

Bulte, J. W. M., & Kraitchman, D. L. (2004) · NMR in Biomedicine · doi:10.1002/nbm.924 · Cited by 1,500

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

Merbach, A. E., Helm, L., & Tóth, É. (2013) · Wiley eBooks · doi:10.1002/9781118503652 · Cited by 1,468

Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging

Jun, Y., Huh, Y., Choi, J., Lee, J.-H., Song, H., Kim, S. J., Yoon, S., Kim, K., Shin, J., Suh, J., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0422155 · Cited by 1,195

Hybrid Gadolinium Oxide Nanoparticles: Multimodal Contrast Agents for in Vivo Imaging

Bridot, J., Faure, A.-C., Laurent, S., Rivière, C., Billotey, C., Hiba, B., Janier, M. F., Josserand, V., Coll, J., Elst, L. V., et al. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068356j · Cited by 787

Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non‐Specific Uptake by Macrophage Cells

Xie, J., Xu, C., Kohler, N., Hou, Y., & Sun, S. (2007) · Advanced Materials · doi:10.1002/adma.200701975 · Cited by 686

Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications

Qiao, R., Yang, C., & Gao, M. (2009) · Journal of Materials Chemistry · doi:10.1039/b902394a · Cited by 685

Development of a T1 Contrast Agent for Magnetic Resonance Imaging Using MnO Nanoparticles

Na, H. B., Lee, J. H., An, K., Park, Y. I., Park, M., Lee, I. S., Nam, D., Kim, S. T., Kim, S., Kim, S., et al. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604775 · Cited by 617

Tailoring a two-dimensional graphene oxide surface: dual T 1 and T 2 MRI contrast agent materials

Peng, E., Wang, F., Tan, S., Zheng, B., Li, S. F. Y., & Xue, J. M. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00902b · Cited by 16

Cell viability and MRI performance of highly efficient polyol-coated magnetic nanoparticles

Arteaga-Cardona, F., Eric, G.-G., Hidalgo-Tobón, S., Lopez‐Vasquez, C., Brito-Barrera, Y. A., Flores‐Tochihuitl, J., Ángulo-Molina, A., Reyes‐Leyva, J., González-Rodríguez, R., Coffer, J. L., et al. (2016) · Journal of Nanoparticle Research · doi:10.1007/s11051-016-3646-0 · Cited by 16

Hyaluronic Acid–Stabilized Fe3O4 Nanoparticles for Promoting In Vivo Magnetic Resonance Imaging of Tumors

Zhang, W., Zhang, Z., Lou, S., Chang, Z., Wen, B., & Zhang, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.918819 · Cited by 15

Simultaneous evaluation of vascular morphology, blood volume and transvascular permeability using SPION‐based, dual‐contrast MRI: imaging optimization and feasibility test

Kwon, H., Shim, W. H., Cho, G., Cho, H. J., Jung, H. S., Lee, C. K., Lee, Y. S., Baek, J. H., Kim, E. J., Suh, J., et al. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3293 · Cited by 15

Synthesis and In Vitro Characterization of Fe3+-Doped Layered Double Hydroxide Nanorings as a Potential Imageable Drug Delivery System

Wang, L., Wang, Y., & Wang, X. (2017) · Materials · doi:10.3390/ma10101140 · Cited by 15

Strategy to prevent cardiac toxicity induced by polyacrylic acid decorated iron MRI contrast agent and investigation of its mechanism

Fu, H., Miao, C., Rui, Y., Hu, F., Shen, M., Xu, H. Y., Zhang, C., Dong, Y. W., Wang, W., Gu, H., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119442 · Cited by 15

D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments

Wang, L., Lai, S.-M., Li, C.-Z., Yu, H., Venkatesan, P., & Lai, P. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051000 · Cited by 13

Water-dispersible magnetite nanoparticles as T 2 MR imaging contrast agent

Manisekaran, R., Velumani, S., & Tapia-Ramı́rez, J. (2017) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/aa59bf · Cited by 12

Exploring precision polymers to fine-tune magnetic resonance imaging properties of iron oxide nanoparticles

King, A. M., Bray, C., Hall, S. C. L., Bear, J. C., Bogart, L. K., Perrier, S., & Davies, G. (2020) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2020.06.036 · Cited by 12

Extremely Small Iron Oxide Nanoparticles Stabilized with Catechol‐Functionalized Multidentate Block Copolymer for Enhanced MRI

Li, P., Xiao, W., Chevallier, P., Biswas, D., Ottenwaelder, X., Fortin, M., & Oh, J. K. (2016) · ChemistrySelect · doi:10.1002/slct.201601035 · Cited by 11

Synthesis of PEGylated Magnetic Nanoparticles With Different Core Sizes

Trekker, J., Jans, K., Damm, H., Mertens, D., Nuytten, T., Vanacken, J., Moshchalkov, V. V., D’Haen, J., Stakenborg, T., Roy, W. V., et al. (2012) · IEEE Transactions on Magnetics · doi:10.1109/tmag.2012.2221687 · Cited by 11

Solid-stabilized emulsion formation using stearoyl lactylate coated iron oxide nanoparticles

Vengsarkar, P. S., & Roberts, C. B. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2627-4 · Cited by 10

Magnetic barcode imaging for contrast agents

Hung, A. H., Lilley, L. M., Hu, F., Harrison, V. S. R., & Meade, T. J. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26175 · Cited by 10

Ultra-Small Superparamagnetic Iron Oxide Nanoparticles Made to Order

Milosevic, B. F., & Motte, L. (2012) · Journal of Bioanalysis & Biomedicine · doi:10.4172/1948-593x.s5-006 · Cited by 9

In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery

Zhang, H., Zhang, J., Zhang, Q., Liu, X., Yang, Y., Ling, Y., & Zhou, Y. (2020) · Nanoscale Advances · doi:10.1039/d0na00714e · Cited by 9

High-Performance T1–T2 Dual-Modal MRI Contrast Agents through Interface Engineering

Zhao, D., Peng, S., Xiao, H., Li, Q., Chai, Y., Sun, H., Liu, R., Yao, L., & Ma, L. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00007 · Cited by 8

Hollow carbon nanospheres embedded with stoichiometric γ-Fe 2 O 3 and GdPO 4 : tuning the nanospheres for in vitro and in vivo size effect evaluation

Zhang, H., Zhang, J., Chen, Y., Wu, T., Lu, M., Chen, Z., Jia, Y., Yang, Y., Ling, Y., & Zhou, Y. (2022) · Nanoscale Advances · doi:10.1039/d1na00771h · Cited by 8

Chain Length Effect of the Multidentate Block Copolymer Strategy to Stabilize Ultrasmall Fe3O4 Nanoparticles

Chan, N., Li, P., & Oh, J. K. (2014) · ChemPlusChem · doi:10.1002/cplu.201402112 · Cited by 8

UTE–ΔR2–ΔR2* combined MR whole‐brain angiogram using dual‐contrast superparamagnetic iron oxide nanoparticles

Jung, H., Jin, S., Cho, J. H., Han, S., Lee, D.-K., & Cho, H. (2016) · NMR in Biomedicine · doi:10.1002/nbm.3514 · Cited by 8

Easy and Efficient Cell Tagging with Block Copolymer-Based Contrast Agents for Sensitive MRI Detection in Vivo

Argibay, B., Trekker, J., Himmelreich, U., Beiras, A., Topete, A., Taboada, P., Pérez‐Mato, M., Iglesias‐Rey, R., Sobrino, T., Rivas, J. M., et al. (2016) · Cell Transplantation · doi:10.3727/096368916x691303 · Cited by 8

Coating influence on inner shell water exchange: An underinvestigated major contributor to SPIONs relaxation properties

Peng, Y., Li, Y., Li, L., Xie, M., Wang, Y., & Butch, C. J. (2023) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2023.102713 · Cited by 7

Magnetic nanoparticles for use in bioimaging

Luo, G., & Zhang, X. (2024) · Biomaterials Science · doi:10.1039/d4bm01145g · Cited by 6

Solvothermal synthesis of polyvinyl pyrrolidone encapsulated, amine-functionalized copper ferrite and its use as a magnetic resonance imaging contrast agent

Heydari, F., Ilosvai, Á. M., Kovács, N., Máthé, D., Kristály, F., Daróczi, L., Kaleta, Z., Viskolcz, B., Nagy, M., Vanyorek, L., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316221 · Cited by 6

Magnetic nanoparticle contrast agents for MRI: structure-property relationships, in vivo applications, and future theranostic directions

Rezaei, B., Mostufa, S., González, K. M. P., Azizi, E., Li, C., Gómez‐Pastora, J., He, R., & Wu, K. (2026) · Nanotechnology · doi:10.1088/1361-6528/ae4e33 · Cited by 8

Citrate stabilized maghemite hydrosol with controllable MRI contrast: Key role of nanoparticle size

Moiseeva, E. O., German, S. V., Komlev, A. S., Rusakov, V. S., Васильевич, З. В., Pavlova, O. S., Perepukhov, A. M., Дмитриенко, А. О., Maslakov, K. I., Griaznova, O. Y., et al. (2024) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2024.172447 · Cited by 4

Functionalized magnetic nanosystems for diagnostic tools and devices: New perspectives in disease diagnosis

Ghorbanizamani, F., Moulahoum, H., Zihnioğlu, F., & Tımur, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19012-4.00009-6 · Cited by 4

Improving nuclear magnetic resonance and electron spin resonance thermometry with size reduction of superparamagnetic iron oxide nanoparticles

Lin, P., Chalise, D., & Cahill, D. G. (2024) · Physical Review Applied · doi:10.1103/physrevapplied.22.044082 · Cited by 4

Synthesis and characterization of gadolinium nanosheets with bound rose bengal: potential use in photodynamic therapy and MRI

Stefanakis, D., Seimenis, I., & Ghanotakis, D. F. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2694-6 · Cited by 4

Scalable fractionation of iron oxide nanoparticles using a CO2 gas-expanded liquid system

Vengsarkar, P. S., Xu, R., & Roberts, C. B. (2015) · Journal of Nanoparticle Research · doi:10.1007/s11051-015-3196-x · Cited by 4

Flow reactor-based batch production of direct radiolabelable superparamagnetic iron oxide for PET/MRI dual-modality contrast agent

Zhong, J. P., Yan, S., Yu, Y., Hu, G., Chen, W., Wang, H., Li, W., Yuan, J., Li, S., Li, X., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160693 · Cited by 3

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

Fernández‐Barahona, I., Ruı́z-Cabello, J., Herranz, F., & Pellico, J. (2018) · Journal of Visualized Experiments · doi:10.3791/58269 · Cited by 3

Super stable water-based magnetic fluid as a dual-mode contrast agent

Li, H., Li, T., Wu, Q., Wang, R., Hong, R., & Li, Y. (2021) · Nanotechnology Reviews · doi:10.1515/ntrev-2021-0068 · Cited by 2

Advances in Nanoparticle‐Based Medical Diagnostic and Therapeutic Techniques

Ekiz, M. Ş., Özkan, A. D., Zengin, A., Tekinay, A. B., & Guler, M. O. (2016) · doi:10.1002/9781118987483.ch9 · Cited by 2

Iron oxides for drug delivery

Rana, B., Singh, P., Varshney, S., Ali, S. W., Joshi, M., & Kale, R. D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95366-5.00012-x · Cited by 1

Multimodal iron oxide nanoparticles for breast cancer theranostics and clinical translation: From bench to bedside

Hussain, Z., Dhaidan, R. M., Alshammari, A., Fikry, F. A., & Thu, H. E. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108111 · Cited by 1

Facile synthesis of porous magnetite microspheres and solvent-induced phase transition

Gan, Z., & Zhao, A. (2013) · Superlattices and Microstructures · doi:10.1016/j.spmi.2013.05.001 · Cited by 1

Ultra-Low-Field MRI and Spin-Lattice Relaxation Time of $^{1}\hbox{H}$ in the Presence of $\hbox{Fe}_{3}\hbox{O}_{4}$ Magnetic Nano-Particles Detected With a High-$T_{\rm C}$ DC-SQUID

Wang, N., Jin, Y., Jiang, F., Zeng, J., Gao, M., Wu, Y., Deng, H., Zheng, G., Li, J., Chen, Y., et al. (2013) · IEEE Transactions on Applied Superconductivity · doi:10.1109/tasc.2013.2238573 · Cited by 1

High ${\rm T}_{1}$ - and ${\rm T}_{2}$ -Contrast Ability of Ultra-Fine PEGylated Iron Oxide Nanoparticles in Ultra-Low Field MRI Measured By a High- ${\rm T}_{\rm c}$ DC-SQUID

Yirong, J., Jia, Q., Hui, D., Wang, N., Fengying, J., Tian, Y., Mingyuan, G., & Dong-Ning, Z. (2014) · IEEE Transactions on Applied Superconductivity · doi:10.1109/tasc.2014.2363630 · Cited by 1

Superparamagnetic Iron Oxide-Based Nanomaterials for Magnetic Resonance Imaging

Niraula, G., Mathpal, M. C., Atoche-Medrano, J. J., Singh, M. K., Coaquira, J. A. H., VERMA, R. C., & Sharma, S. K. (2021) · Topics in mining, metallurgy and materials engineering · doi:10.1007/978-3-030-79960-1_7 · Cited by 2

Engineering genomes for biofuels

Ahmad, N., Mehmood, M., Burgess, S., & Khan, M. S. (2016) · CRC Press eBooks · doi:10.1201/b19543-29

Dual contrast microvascular MRI

Jung, H. (2016) · Scholarworks@UNIST (Ulsan National Institute of Science and Technology)

Magnetic nanoparticles with multifunctional water-soluble polymers for bioapplications

Majeed, M. I., Hanif, M. A., Nawaz, H., & Tan, B. (2016) · CRC Press eBooks · doi:10.1201/b19543-25

Diagnosis

Savari, M.-N., & Jabali, A. (2023) · Nanomedicine and nanotoxicology · doi:10.1007/978-981-99-6507-6_8

Additional file 1 of Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile

Suh, M., Park, J. Y., Ko, G. B., Kim, J. Y., Hwang, D. W., Rees, L., Conway, G. E., Doak, S. H., Kang, H., Lee, N., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26315545

Tunable magnetic properties and enhanced T2 relaxivity in Sr-doped LaMnO3 nanoparticles for biomedical imaging

Vignesh, G., Ashokkumar, M., & Murugan, S. (2026) · Materials Science and Engineering B · doi:10.1016/j.mseb.2026.119401 · Cited by 1

Advances in holmium-doped nanostructures for cancer theranostics

Osial, M. E., Pietrzyk-Thel, P., Hilus, J., Wyszogrodzka, G., Nwaji, N. N., Kempa, K., & Giersig, M. (2026) · Journal of Materials Chemistry B · doi:10.1039/d5tb01701g

Engineered Zn-doped magnetite nanoparticles as high-performance tracers for ultrasensitive atomic magnetometry

Xiao, H., Sun, X., Li, Q., shen, G., Sun, H., Yao, L., & Li, W. (2026) · Nanoscale · doi:10.1039/d6nr01514j

Facile synthesis of water-soluble Fe3O4 and Fe3O4@PVA nanoparticles for dual-contrast T1- and T2-weighted magnetic resonance imaging

Kushwaha, P., & Chauhan, P. (2022) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2022.09.009 · Cited by 20

One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement

Dai, L., Liu, Y., Wang, Z., Guo, F., Shi, D., & Zhang, B. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.04.041 · Cited by 40

Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent

Deng, L., Jiang, H., Lu, F., Wang, H., Pu, Y., Wu, C., Hong-jie, T., Xu, Y., Chen, T., Zhu, J., et al. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s271461 · Cited by 36

Synthesis and Application of Magnetic Iron Oxide Nanoparticles as High Efficiency Magnetic Resonance Imaging Contrast Agent

Jun, W., Zhang, B., Gao, Y., Wang, L., Song-Bo, X., Li, X., & Fa-Bao, G. (2015) · Journal of Inorganic Materials · doi:10.15541/jim20140178 · Cited by 2

T1–T2 Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes

Szpak, A., Fiejdasz, S., Prendota, W., Strączek, T., Kapusta, C., Szmyd, J. S., Nowakowska, M., & Zapotoczny, S. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2678-6 · Cited by 122