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Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson’s disease by reducing oxidative stress
Open accessAbstract
Resveratrol, a potent natural antioxidant, possesses a wide range of pharmacological activities, but its oral bioavailability is very low due to its extensive hepatic and presystemic metabolism. The aim of the present study was to formulate a kinetically stable nanoemulsion (o/w) using vitamin E:sefsol (1:1) as the oil phase, Tween 80 as the surfactant and Transcutol P as the co-surfactant for the better management of Parkinson's disease. The nanoemulsion was prepared by a spontaneous emulsification method, followed by high-pressure homogenization. Ternary phase diagrams were constructed to locate the area of nanoemulsion. The prepared formulations were studied for globule size, zeta potential, refractive index, viscosity, surface morphology and in vitro and ex vivo release. The homogenized formulation, which contained 150 mg ml(-1) of resveratrol, showed spherical globules with an average globule diameter of 102 ± 1.46 nm, a least poly dispersity index of 0.158 ± 0.02 and optimal zeta potential values of -35 ± 0.02. The cumulative percentage drug release for the pre-homogenized resveratrol suspension, pre-homogenized nanoemulsion and post-homogenized nanoemulsion were 24.18 ± 2.30%, 54.32 ± 0.95% and 88.57 ± 1.92%, respectively, after 24 h. The ex vivo release also showed the cumulative percentage drug release of 85.48 ± 1.34% at 24 h. The antioxidant activity determined by using a DPPH assay showed high scavenging efficiency for the optimized formulation. Pharmacokinetic studies showed the higher concentration of the drug in the brain (brain/blood ratio: 2.86 ± 0.70) following intranasal administration of the optimized nanoemulsion. Histopathological studies showed decreased degenerative changes in the resveratrol nanoemulsion administered groups. The levels of GSH and SOD were significantly higher, and the level of MDA was significantly lower in the resveratrol nanoemulsion treated group.
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“Furthermore, histopathological studies showed decreased degenerative changes in the case of resveratrol NE administration.”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [58]
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“Pharmacokinetic and brain-targeting studies carried out on Wistar rats demonstrated a higher concentration of the drug in the brain after nasal administration of NEs.”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [58]
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“Significantly high ex vivo trans-nasal mucosal fluxes were found using a Franz diffusion cell on porcine nasal mucosa.”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [58]
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Oxidative and nitrative stress in neurodegeneration
Cobb, C. A., & Cole, M. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.020 · Cited by 306
Nanoemulsions for “Nose-to-Brain” Drug Delivery
Bonferoni, M. C., Rossi, S., Sandri, G., Ferrari, F., Gavini, E., Rassu, G., & Giunchedi, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020084 · Cited by 269
Molecular mechanisms of anticancer effect of rutin
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Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies
Pires, P. C., & Santos, A. O. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.047 · Cited by 228
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Metadata
- Authors
- Pangeni, R., Sharma, S., Mustafa, G., Ali, J., & Baboota, S.
- Affiliations
- Jamia Hamdard (IN)
- Corresponding author
- Baboota, Sanjula
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2014-11-13
- Volume
- 25
- Issue
- 48
- Pages
- 485102
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W1967033368
- Cited by
- 192
- References
- 32
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 23 · 2023: 24 · 2022: 22 · 2021: 18 · 2020: 23 · 2019: 18 · 2018: 10 · 2017: 14 · 2016: 9 · 2015: 8
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- resveratrol, nanoemulsions, Parkinson's disease, vitamin E, brain targeting, intranasal drug delivery, oxidative stress, antioxidant activity, high-pressure homogenization, drug bioavailability, pharmacokinetics, lipid peroxidation, glutathione, superoxide dismutase, malondialdehyde, neuroprotection
- MeSH terms
- Resveratrol, Animals, Antioxidants, Biological Availability, Brain, Chemistry, Pharmaceutical, Emulsions, Female, Male, Parkinson Disease, Particle Size, Polysorbates, Solubility, Stilbenes, Swine, Viscosity, Vitamin E, Rats, Wistar, Oxidative Stress, Rats, Nanoparticles
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