Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting
Abstract
INTRODUCTION: The blood-brain barrier (BBB) represents a stringent barrier for delivery of neurotherapeutics in vivo. An attempt to overcome this barrier is represented by the direct transport of drugs from the nose to the brain along the olfactory and trigeminal nerve pathways. These nerve pathways initiate in the nasal cavity at olfactory neuroepithelium and terminate in the brain. An enormous range of neurotherapeutics, both macromolecules and low molecular weight drugs, can be delivered to the central nervous system (CNS) via this route. AREAS COVERED: Present review highlights the literature on the anatomy-physiology of the nasal cavity, pathways and mechanisms of neurotherapeutic transport across nasal epithelium and their biofate and various strategies to enhance direct nose to brain drug delivery. The authors also emphasize a variety of drug molecules and carrier systems delivered via this route for treating CNS disorders. Patents related to direct nose to brain drug delivery systems have also been listed. EXPERT OPINION: Direct nose to brain drug delivery system is a practical, safe, non-invasive and convenient form of formulation strategy and could be viewed as an excellent alternative approach to conventional dosage forms. Existence of a direct transport route from the nasal cavity to the brain, bypassing the BBB, would offer an exciting mode of delivering neurotherapeutic agents.
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Because of the direct connection provided by the olfactory and trigeminal nerves between the olfactory epithelium and the brain, drug targeting can be achieved by administering formulations onto the nasal mucosa.
“Thanks to the direct connection provided by the olfactory and trigeminal nerves present between the olfactory epithelium and the brain, drug targeting can be achieved with the administration of formulations onto nasal mucosa [10,11,12].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [11]
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- Authors
- Pardeshi, C. V., & Belgamwar, V. S.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2013-04-16
- Volume
- 10
- Issue
- 7
- Pages
- 957-972
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2162752807
- Cited by
- 482
- References
- 92
- Citations by year
- 2026: 44 · 2025: 41 · 2024: 50 · 2023: 48 · 2022: 39 · 2021: 65 · 2020: 43 · 2019: 50 · 2018: 36 · 2017: 20 · 2016: 13 · 2015: 14 · 2014: 12 · 2013: 6
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- nose-to-brain delivery, blood-brain barrier bypass, intranasal drug delivery, olfactory epithelium, nasal epithelium, neurotherapeutics, brain drug delivery, drug carriers, patents
- MeSH terms
- Administration, Intranasal, Biological Transport, Blood-Brain Barrier, Brain, Pharmaceutical Preparations, Humans, Nasal Mucosa, Olfactory Pathways, Trigeminal Nerve, Drug Delivery Systems
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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