Cited by 482Advanced Drug Delivery SystemsBarrier Structure and Function StudiesInhalation and Respiratory Drug Delivery

Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

Pardeshi, Chandrakantsing Vijaysing, Belgamwar, Veena Shailendra·2013·Expert Opinion on Drug Delivery

Abstract

INTRODUCTION: The blood-brain barrier (BBB) represents a stringent barrier for delivery of neurotherapeutics in vivo. An attempt to overcome this barrier is represented by the direct transport of drugs from the nose to the brain along the olfactory and trigeminal nerve pathways. These nerve pathways initiate in the nasal cavity at olfactory neuroepithelium and terminate in the brain. An enormous range of neurotherapeutics, both macromolecules and low molecular weight drugs, can be delivered to the central nervous system (CNS) via this route. AREAS COVERED: Present review highlights the literature on the anatomy-physiology of the nasal cavity, pathways and mechanisms of neurotherapeutic transport across nasal epithelium and their biofate and various strategies to enhance direct nose to brain drug delivery. The authors also emphasize a variety of drug molecules and carrier systems delivered via this route for treating CNS disorders. Patents related to direct nose to brain drug delivery systems have also been listed. EXPERT OPINION: Direct nose to brain drug delivery system is a practical, safe, non-invasive and convenient form of formulation strategy and could be viewed as an excellent alternative approach to conventional dosage forms. Existence of a direct transport route from the nasal cavity to the brain, bypassing the BBB, would offer an exciting mode of delivering neurotherapeutic agents.

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Crossref · 10.1517/17425247.2013.790887

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83 of 83 references verified0 citation errors · 0 not checkable

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  • Because of the direct connection provided by the olfactory and trigeminal nerves between the olfactory epithelium and the brain, drug targeting can be achieved by administering formulations onto the nasal mucosa.

    “Thanks to the direct connection provided by the olfactory and trigeminal nerves present between the olfactory epithelium and the brain, drug targeting can be achieved with the administration of formulations onto nasal mucosa [10,11,12].”

    From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [11]

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Authors
Pardeshi, C. V., & Belgamwar, V. S.
Venue
Expert Opinion on Drug Delivery
Published
2013-04-16
Volume
10
Issue
7
Pages
957-972
ISSN
  • 1742-5247 (ISSN-L)
  • 1744-7593
OpenAlex
W2162752807
Cited by
482
References
92
Citations by year
2026: 44 · 2025: 41 · 2024: 50 · 2023: 48 · 2022: 39 · 2021: 65 · 2020: 43 · 2019: 50 · 2018: 36 · 2017: 20 · 2016: 13 · 2015: 14 · 2014: 12 · 2013: 6
FWCI
1.89
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Drug Delivery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords
nose-to-brain delivery, blood-brain barrier bypass, intranasal drug delivery, olfactory epithelium, nasal epithelium, neurotherapeutics, brain drug delivery, drug carriers, patents
MeSH terms
Administration, Intranasal, Biological Transport, Blood-Brain Barrier, Brain, Pharmaceutical Preparations, Humans, Nasal Mucosa, Olfactory Pathways, Trigeminal Nerve, Drug Delivery Systems

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