The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Physical principles of intracellular organization via active and passive phase transitions
Abstract
Exciting recent developments suggest that phase transitions represent an important and ubiquitous mechanism underlying intracellular organization. We describe key experimental findings in this area of study, as well as the application of classical theoretical approaches for quantitatively understanding these data. We also discuss the way in which equilibrium thermodynamic driving forces may interface with the fundamentally out-of-equilibrium nature of living cells. In particular, time and/or space-dependent concentration profiles may modulate the phase behavior of biomolecules in living cells. We suggest future directions for both theoretical and experimental work that will shed light on the way in which biological activity modulates the assembly, properties, and function of viscoelastic states of living matter.
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Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757 · cited 1×
“The most notable quantitative studies were those focused on the possibility of 2D phase separation within the cell membrane, which may give rise to ‘lipid rafts’ that organize membrane associated receptors [5].”
BackgroundInherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M., & Stefani, M. (2002) · Nature · doi:10.1038/416507a · Cited by 2,434
Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.017 · Cited by 2,012
Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
An, S., Kumar, R., Sheets, E. D., & Benkovic, S. J. (2008) · Science · doi:10.1126/science.1152241 · Cited by 585 · cited 1×
“There are also condensates comprised of metabolic enzymes such as the purinisome [20], and protein condensates enriched in Wnt and other molecules key for intracellular signalling [21–27].”
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Cited by
A framework for understanding the functions of biomolecular condensates across scales
Lyon, A. S., Peeples, W. B., & Rosen, M. K. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00303-z · Cited by 895
Pessina, F., Giavazzi, F., Yin, Y., Gioia, U., Vitelli, V., Galbiati, A., Barozzi, S., Garre, M., Oldani, A., Flaus, A., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0392-4 · Cited by 360
The overlapping genetics of amyotrophic lateral sclerosis and frontotemporal dementia
Abramzon, Y. A., Fratta, P., Traynor, B. J., & Chia, R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00042 · Cited by 244
Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria
Cohan, M. C., & Pappu, R. V. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.04.011 · Cited by 104
Hochmair, J., Exner, C., Franck, M., Dominguez‐Baquero, A., Diez, L., Brognaro, H., Kraushar, M. L., Mielke, T., Radbruch, H., Kaniyappan, S., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2021108882 · Cited by 106
Metadata
- Authors
- Berry, J., Brangwynne, C. P., & Haataja, M.
- Venue
- Reports on Progress in Physics
- Publisher
- IOP Publishing
- Published
- 2018-02-23
- Volume
- 81
- Issue
- 4
- Pages
- 046601
- ISSN
- 0034-4885 (ISSN-L)
- 1361-6633
- OpenAlex
- W2784297130
- Cited by
- 452
- References
- 4
- FWCI
- 14.37
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
