Signal-independent noise in intracortical brain–computer interfaces causes movement time properties inconsistent with Fitts’ law
Open accessAbstract
Objective . Do movements made with an intracortical BCI (iBCI) have the same movement time properties as able-bodied movements? Able-bodied movement times typically obey Fitts’ law: MT = a + b log 2 ( D / R ) (where MT is movement time, D is target distance, R is target radius, and a , b are parameters). Fitts’ law expresses two properties of natural movement that would be ideal for iBCIs to restore: (1) that movement times are insensitive to the absolute scale of the task (since movement time depends only on the ratio D / R ) and (2) that movements have a large dynamic range of accuracy (since movement time is logarithmically proportional to D / R ). Approach . Two participants in the BrainGate2 pilot clinical trial made cortically controlled cursor movements with a linear velocity decoder and acquired targets by dwelling on them. We investigated whether the movement times were well described by Fitts’ law. Main results . We found that movement times were better described by the equation MT = a + b D + c R − 2 , which captures how movement time increases sharply as the target radius becomes smaller, independently of distance. In contrast to able-bodied movements, the iBCI movements we studied had a low dynamic range of accuracy (absence of logarithmic proportionality) and were sensitive to the absolute scale of the task (small targets had long movement times regardless of the D / R ratio). We argue that this relationship emerges due to noise in the decoder output whose magnitude is largely independent of the user’s motor command (signal-independent noise). Signal-independent noise creates a baseline level of variability that cannot be decreased by trying to move slowly or hold still, making targets below a certain size very hard to acquire with a standard decoder. Significance . The results give new insight into how iBCI movements currently differ from able-bodied movements and suggest that restoring a Fitts’ law-like relationship to iBCI movements may require non-linear decoding strategies.
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Decoding accuracy is the main factor limiting the speed of point-and-click BCIs.
“The speed of point-and-click BCIs is limited primarily by decoding accuracy.”
From High-performance brain-to-text communication via handwriting (2021) · cites this paper as [22]
The Results (Effect of gain on movement time; page unavailable) report that increasing cursor speed made movements fast but inaccurate, and the Introduction identifies signal-independent decoding noise as the root cause of the movement-time properties observed. This supports a speed–accuracy constraint in the intracortical cursor systems studied, but not the broader claim that decoding accuracy is the primary speed limit for point-and-click BCIs generally. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn parameter optimization, cursor gain is raised to increase typing speed until decoding errors make the cursor uncontrollable.
“During parameter optimization, the cursor gain is increased so as to increase typing rate, until the cursor moves so quickly that it becomes uncontrollable due to decoding errors22.”
From High-performance brain-to-text communication via handwriting (2021) · cites this paper as [22]
The Results section, “Effect of gain on movement time” (page unavailable), reports that increasing gain initially shortened target-acquisition time, but higher gains made cursor movements fast, inaccurate, and uncontrollable around targets. The paper relates this difficulty to decoding noise, but it studies cursor target acquisition, not typing rate, and does not describe the claimed typing-speed optimization procedure. (LLM, conf=0.85)
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Cites
The information capacity of the human motor system in controlling the amplitude of movement.
Fitts, P. M. (1954) · Journal of Experimental Psychology · doi:10.1037/h0055392 · Cited by 6,466 · see citing works
The information capacity of the human motor system in controlling the amplitude of movement.
Fitts, P. M. (1992) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.121.3.262 · Cited by 6,291 · see citing works
Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295 · see citing works
Self-citationReach and grasp by people with tetraplegia using a neurally controlled robotic arm
Hochberg, L. R., Bacher, D., Jarosiewicz, B., Masse, N. Y., Simeral, J. D., Vogel, J., Haddadin, S., Liu, J., Cash, S. S., van der Smagt, P., et al. (2012) · Nature · doi:10.1038/nature11076 · Cited by 2,719 · see citing works
Self-citationSignal-dependent noise determines motor planning
Harris, C. M., & Wolpert, D. M. (1998) · Nature · doi:10.1038/29528 · Cited by 2,498 · see citing works
High-performance neuroprosthetic control by an individual with tetraplegia
Collinger, J. L., Wodlinger, B., Downey, J. E., Wang, W., Tyler-Kabara, E. C., Weber, D. J., McMorland, A. J., Velliste, M., Boninger, M. L., & Schwartz, A. B. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61816-9 · Cited by 1,848 · see citing works
Learning to control a brain–machine interface for reaching and grasping by primates
Carmena, J. M., Lebedev, M. A., Crist, R. E., O'Doherty, J. E., Santucci, D. M., Dimitrov, D. F., Patil, P. G., Henriquez, C. S., & Nicolelis, M. A. L. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000042 · Cited by 1,761 · see citing works
Motor-output variability: A theory for the accuracy of rapid motor acts.
Schmidt, R. A., Zelaznik, H. N., Hawkins, B., Frank, J. S., & Quinn, J. T. (1979) · Psychological Review · doi:10.1037/0033-295x.86.5.415 · Cited by 1,557 · see citing works
Optimality in human motor performance: Ideal control of rapid aimed movements.
Meyer, D. E., Abrams, R. A., Kornblum, S., Wright, C. E., & Keith Smith, J. E. (1988) · Psychological Review · doi:10.1037/0033-295x.95.3.340 · Cited by 1,406 · see citing works
Motor Cortical Representation of Speed and Direction During Reaching
Moran, D. W., & Schwartz, A. B. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.5.2676 · Cited by 813 · see citing works
Reproducibility and Variability in Neural Spike Trains
van Steveninck, R. R. D. R., Lewen, G. D., Strong, S. P., Köberle, R., & Bialek, W. (1997) · Science · doi:10.1126/science.275.5307.1805 · Cited by 680 · see citing works
A high-performance neural prosthesis enabled by control algorithm design
Gilja, V., Nuyujukian, P., Chestek, C. A., Cunningham, J. P., Yu, B. M., Fan, J. M., Churchland, M. M., Kaufman, M. T., Kao, J. C., Ryu, S. I., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3265 · Cited by 564 · see citing works
Self-citationSources of Signal-Dependent Noise During Isometric Force Production
Jones, K. E., Hamilton, A. F. D. C., & Wolpert, D. M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.3.1533 · Cited by 556 · see citing works
Simeral, J. D., Kim, S.-P., Black, M. J., Donoghue, J. P., & Hochberg, L. R. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/2/025027 · Cited by 496 · see citing works
Self-citationViral Discovery and Sequence Recovery Using DNA Microarrays
Wang, D., Urisman, A., Liu, Y., Springer, M., Ksiazek, T. G., Erdman, D. D., Mardis, E. R., Hickenbotham, M. T., Magrini, V. J., Eldred, J. M., et al. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000002 · Cited by 465 · see citing works
Spatiotemporal Tuning of Motor Cortical Neurons for Hand Position and Velocity
Paninski, L., Fellows, M. R., Hatsopoulos, N. G., & Donoghue, J. P. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00587.2002 · Cited by 392 · see citing works
An Investigation of Fitts’ Law Using a Wide Range of Movement Amplitudes
Langolf, G. D., Chaffin, D. B., & Foulke, J. A. (1976) · Journal of Motor Behavior · doi:10.1080/00222895.1976.10735061 · Cited by 374 · see citing works
Temporal Complexity and Heterogeneity of Single-Neuron Activity in Premotor and Motor Cortex
Churchland, M. M., & Shenoy, K. V. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00095.2007 · Cited by 356 · see citing works
Self-citationAccuracy of planar reaching movements
Gordon, J., Ghilardi, M. F., Cooper, S. E., & Ghez, C. P. (1994) · Experimental Brain Research · doi:10.1007/bf00241416 · Cited by 351 · see citing works
The Impact of Control-Display Gain on User Performance in Pointing Tasks
Casiez, G., Vogel, D., Balakrishnan, R., & Cockburn, A. (2008) · Human-Computer Interaction · doi:10.1080/07370020802278163 · Cited by 347 · see citing works
Clinical translation of a high-performance neural prosthesis
Gilja, V., Pandarinath, C., Blabe, C. H., Nuyujukian, P., Simeral, J. D., Sarma, A. A., Sorice, B. L., Perge, J. A., Jarosiewicz, B., Hochberg, L. R., et al. (2015) · Nature Medicine · doi:10.1038/nm.3953 · Cited by 343 · see citing works
Self-citationJarosiewicz, B., Sarma, A. A., Bacher, D., Masse, N. Y., Simeral, J. D., Sorice, B., Oakley, E. M., Blabe, C., Pandarinath, C., Gilja, V., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac7328 · Cited by 340 · see citing works
Self-citationStatistical Issues in the Analysis of Neuronal Data
Kass, R. E., Ventura, V., & Brown, E. N. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00648.2004 · Cited by 295 · see citing works
Perge, J. A., Homer, M. L., Malik, W. Q., Cash, S., Eskandar, E., Friehs, G., Donoghue, J. P., & Hochberg, L. R. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/3/036004 · Cited by 243 · see citing works
Self-citationBeyond Poisson: Increased Spike-Time Regularity across Primate Parietal Cortex
Maimon, G., & Assad, J. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.021 · Cited by 228 · see citing works
Bootsma, R. J., Marteniuk, R. G., MacKenzie, C. L., & Zaal, F. T. J. M. (1994) · Experimental Brain Research · doi:10.1007/bf00233990 · Cited by 227 · see citing works
Making brain–machine interfaces robust to future neural variability
Sussillo, D., Stavisky, S. D., Kao, J. C., Ryu, S. I., & Shenoy, K. V. (2016) · Nature Communications · doi:10.1038/ncomms13749 · Cited by 214 · see citing works
Self-citationSpatial Organization and Magnitude of Orientation Contrast Interactions in Primate V1
Jones, H. E., Wang, W., & Sillito, A. M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00403.2001 · Cited by 195 · see citing works
Extracting kinematic parameters for monkey bipedal walking from cortical neuronal ensemble activity
Fitzsimmons, N. A. (2009) · Frontiers in Integrative Neuroscience · doi:10.3389/neuro.07.003.2009 · Cited by 186 · see citing works
A recurrent neural network for closed-loop intracortical brain–machine interface decoders
Sussillo, D., Nuyujukian, P., Fan, J. M., Kao, J. C., Stavisky, S. D., Ryu, S. I., & Shenoy, K. V. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/2/026027 · Cited by 183 · see citing works
Self-citationUnscented Kalman Filter for Brain-Machine Interfaces
Li, Z., O’Doherty, J. E., Hanson, T., Lebedev, M., Henriquez, C. S., & Nicolelis, M. A. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006243 · Cited by 182 · see citing works
Comparison of Six Cursor Control Devices Based on Fitts' Law Models
Epps, B. W. (1986) · Proceedings of the Human Factors Society Annual Meeting · doi:10.1177/154193128603000403 · Cited by 147 · cited 8× · see citing works
“LinPow can therefore describe the sharp increase in movement time we observed when target radius becomes too small (supplemental figures 4(A) and (B) show examples). To validate LinPow, we performed a cross-validated comparison of its ability to predict movement times versus Fitts’ law. LinPow outperformed Fitts’ law…”
MethodResultInfluentialAn Optimization Principle for Determining Movement Duration
Tanaka, H., Krakauer, J. W., & Ning Qian, A. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00751.2005 · Cited by 136 · see citing works
Chase, S. M., Schwartz, A. B., & Kass, R. E. (2009) · Neural Networks · doi:10.1016/j.neunet.2009.05.005 · Cited by 132 · see citing works
Shanechi, M. M., Orsborn, A. L., & Carmena, J. M. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004730 · Cited by 114 · see citing works
Accuracy Constraints Upon Rapid Elbow Movements
Corcos, D. M., Gottlieb, G. L., & Agarwal, G. C. (1988) · Journal of Motor Behavior · doi:10.1080/00222895.1988.10735445 · Cited by 100 · see citing works
Efficient Decoding With Steady-State Kalman Filter in Neural Interface Systems
Malik, W. Q., Truccolo, W., Brown, E. N., & Hochberg, L. R. (2010) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2010.2092443 · Cited by 98 · see citing works
Self-citationPostural and resting tremor in the upper limb
Morrison, S., & Newell, K. M. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00302-8 · Cited by 91 · see citing works
Gain effects on performance using a head-controlled computer input device
LIN, M. L., Radwin, R. G., & Vanderheiden, G. C. (1992) · Ergonomics · doi:10.1080/00140139208967804 · Cited by 74 · see citing works
Intention estimation in brain–machine interfaces
Fan, J. M., Nuyujukian, P., Kao, J. C., Chestek, C. A., Ryu, S. I., & Shenoy, K. V. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/1/016004 · Cited by 68 · see citing works
Self-citationFitts’ Law with an Isometric Controller
Kantowitz, B. H., & Elvers, G. C. (1988) · Journal of Motor Behavior · doi:10.1080/00222895.1988.10735432 · Cited by 67 · see citing works
Computational motor control: feedback and accuracy
Guigon, E., Baraduc, P., & Desmurget, M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06028.x · Cited by 65 · see citing works
Motor cortical control of movement speed with implications for brain-machine interface control
Golub, M. D., Yu, B. M., Schwartz, A. B., & Chase, S. M. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00391.2013 · Cited by 63 · see citing works
Feedback control policies employed by people using intracortical brain–computer interfaces
Willett, F. R., Pandarinath, C., Jarosiewicz, B., Murphy, B. A., Memberg, W. D., Blabe, C. H., Saab, J., Walter, B. L., Sweet, J. A., Miller, J. P., et al. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/14/1/016001 · Cited by 61 · see citing works
Self-citationInternal models for interpreting neural population activity during sensorimotor control
Golub, M. D., Yu, B. M., & Chase, S. M. (2015) · eLife · doi:10.7554/elife.10015 · Cited by 59 · see citing works
Toward a whole-body neuroprosthetic
Lebedev, M., & Nicolelis, M. A. L. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53815-4.00018-2 · Cited by 53 · see citing works
Perel, S., Sadtler, P. T., Oby, E. R., Ryu, S. I., Tyler‐Kabara, E. C., Batista, A. P., & Chase, S. M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00293.2014 · Cited by 51 · see citing works
Two-Part Models Capture the Impact of Gain on Pointing Performance
Shoemaker, G. B. D., Tsukitani, T., Kitamura, Y., & Booth, K. S. (2012) · ACM Transactions on Computer-Human Interaction · doi:10.1145/2395131.2395135 · Cited by 47 · see citing works
Bye, R. T., & Neilson, P. D. (2008) · Human Movement Science · doi:10.1016/j.humov.2008.04.003 · Cited by 36 · see citing works
Target-Directed Movements at a Comfortable Pace: Movement Duration and Fitts's Law
Young, S. J., Pratt, J., & Chau, T. T. (2009) · Journal of Motor Behavior · doi:10.3200/jmbr.41.4.339-346 · Cited by 36 · see citing works
Fitts’ Law as a Function of System Dynamics and Target Uncertainty
Jagacinski, R. J., Hartzell, E. J., Ward, S. L., & Bishop, K. (1978) · Journal of Motor Behavior · doi:10.1080/00222895.1978.10735145 · Cited by 30 · see citing works
Sachs, N. A., Ruiz-Torres, R., Perreault, E. J., & Miller, L. E. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/1/016009 · Cited by 23 · see citing works
Pointing with the ankle: the speed-accuracy trade-off
Michmizos, K. P., & Krebs, H. I. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3773-0 · Cited by 22 · see citing works
Advancing brain-machine interfaces: moving beyond linear state space models
Rouse, A. G., & Schieber, M. H. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00108 · Cited by 16 · see citing works
Gain and Target Size Effects on Cursor-Positioning Time with a Mouse
Bohan, M., Thompson, S., Scarlett, D. S., & Chaparro, A. (2003) · Proceedings of the Human Factors and Ergonomics Society Annual Meeting · doi:10.1177/154193120304700416 · Cited by 13 · see citing works
Characterizing and Predicting Submovements during Human Three-Dimensional Arm Reaches
Liao, J., & Kirsch, R. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103387 · Cited by 12 · see citing works
Self-citationMarathe, A. R., & Taylor, D. M. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/4/046031 · Cited by 11 · see citing works
Effects of Adaptation to Altered Display Gain on the Control of Single Aimed Movements
van Doorn, R. R. A., & Unema, P. (2005) · Motor Control · doi:10.1123/mcj.9.1.3 · Cited by 11 · see citing works
Limb segment information transmission capacity.
Leisman, G. (1989) · PubMed · Cited by 7 · see citing works
Empirical Movement Models for Brain Computer Interfaces
Matlack, C., Chizeck, H. J., & Moritz, C. T. (2016) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2016.2584101 · Cited by 3 · see citing works
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Patrick-Krueger, K. M., Burkhart, I., & Contreras-Vidal, J. L. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00239-5 · Cited by 130 · see citing works
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Pandarinath, C., & Bensmaı̈a, S. J. (2021) · Physiological Reviews · doi:10.1152/physrev.00034.2020 · Cited by 76 · see citing works
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Young, D. R., Willett, F. R., Memberg, W. D., Murphy, B., Walter, B. L., Sweet, J., Miller, J. P., Hochberg, L. R., Kirsch, R. F., & Ajiboye, A. B. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa9ee8 · Cited by 56 · see citing works
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- Authors
- Willett, F. R., Murphy, B. A., Memberg, W. D., Blabe, C. H., Pandarinath, C., Walter, B. L., Sweet, J. A., Miller, J. P., Henderson, J. M., Shenoy, K. V., Hochberg, L. R., Kirsch, R. F., & Ajiboye, A. B.
- Affiliations
- Cleveland FES Center (US)
- Stanford University (US)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- ORCID
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2017-02-08
- Volume
- 14
- Issue
- 2
- Pages
- 026010
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- PMC
- PMC5371026
- OpenAlex
- W2586138220
- Cited by
- 16
- References
- 60
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01HD10018)
- Craig H. Neilsen Foundation
- National Science Foundation (GRFP DGE-0951783)
- Samuel and Betsy Reeves
- National Institutes of Health (N01HD53403)
- Massachusetts General Hospital
- Rehabilitation Research and Development Service (A6779I)
- National Institute on Deafness and Other Communication Disorders (R01DC009899)
- Stanford BioX-NeuroVentures
- Larry and Pamela Garlick
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Physical Sciences › Computer Science › Human-Computer Interaction › Gaze Tracking and Assistive Technology
- Keywords
- intracortical brain-computer interfaces, Fitts' law, movement time, signal-independent noise, target distance, cursor control, neural decoding
- MeSH terms
- Computer Simulation, Electroencephalography, Evoked Potentials, Female, Humans, Male, Middle Aged, Models, Neurological, Movement, Psychomotor Performance, Sensitivity and Specificity, Reproducibility of Results, Artifacts, Signal-To-Noise Ratio, Brain-Computer Interfaces
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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