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Stimuli-responsive polymers and their applications in drug delivery
Abstract
Interest in stimuli-responsive polymers is steadily gaining increasing momentum especially in the fields of controlled and self-regulated drug delivery. Delivery systems based on these polymers are developed to closely resemble the normal physiological process of the diseased state ensuring optimum drug release according to the physiological need. Also termed 'environmental-sensitive' or 'smart', these polymers experience rapid changes in their microstructure from a hydrophilic to a hydrophobic state triggered by small changes in the environment. The changes are reversible; therefore, the polymer is capable of returning to its initial state as soon as the trigger is removed. Stimuli may occur internally (e.g. a change in pH in certain organs or diseased states, a change in temperature or the presence of specific enzymes or antigens). External stimuli include magnetic or electric fields, light, ultrasound, etc. This review will delve into the various internally and externally stimuli-responsive polymers and the drug delivery systems that exploit them.
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Cites
Polymeric micelles—A new generation of colloidal drug carriers
Jones, M.-C., & Leroux, J.-C. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00039-9 · Cited by 1,256
Drug targeting using thermally responsive polymers and local hyperthermia
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Cited by
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Controlled Drug Delivery Systems: Current Status and Future Directions
Adepu, S., & Ramakrishna, S. (2021) · Molecules · doi:10.3390/molecules26195905 · Cited by 1,691
Biodegradable synthetic polymers: Preparation, functionalization and biomedical application
Tian, H., Tang, Z., Zhuang, X., Chen, X., & Jing, X. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.06.004 · Cited by 1,293
Nam, S., & Mooney, D. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00798 · Cited by 764
Metadata
- Authors
- Bawa, P., Pillay, V., Choonara, Y. E., & du Toit, L. C.
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2009-03-05
- Volume
- 4
- Issue
- 2
- Pages
- 022001
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W2127955898
- Cited by
- 641
- References
- 2
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bawa, P., Pillay, V., Choonara, Y. E., & du Toit, L. C. (2009). Stimuli-responsive polymers and their applications in drug delivery. Biomedical Materials. https://doi.org/10.1088/1748-6041/4/2/022001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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