Biomaterial surface chemistry dictates adherent monocyte/macrophage cytokine expression in vitro
Abstract
An in vitro human monocyte culture system was used to determine whether adherent monocyte/macrophage cytokine production was influenced by material surface chemistry. A polyethylene terephthalate (PET) base surface was modified by photograft copolymerization to yield hydrophobic, hydrophilic, anionic and cationic surfaces. Freshly isolated human monocytes were cultured onto the surfaces for periods up to 10 days in the presence or absence of interleukin-4 (IL-4). Semi-quantitative RT-PCR analysis on days 3, 7 and 10 of cell culture revealed that interleukin-10 (IL-10) expression significantly increased in cells adherent to the hydrophilic and anionic surfaces but significantly decreased in the cationic surface adherent monocytes/macrophages. Conversely, interleukin-8 (IL-8) expression was significantly decreased in cells adherent to the hydrophilic and anionic surfaces. Further analysis revealed that the hydrophilic and anionic surfaces inhibited monocyte adhesion and IL-4-mediated macrophage fusion into foreign body giant cells (FBGCs). Therefore, hydrophilic and anionic surfaces promote an anti-inflammatory type of response by dictating selective cytokine production by biomaterial adherent monocytes and macrophages. These studies contribute information necessary to enhance our understanding of biocompatibility to be used to improve the in vivo lifetime of implanted medical devices and prostheses.
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Macrophages on surfaces that inhibited monocyte adhesion and IL-4 mediated macrophage fusion had a different cytokine expression profile than surfaces that promoted fusion.
“It was found that macrophages on surfaces that inhibited monocyte adhesion and IL-4 mediated macrophage fusion had a different cytokine expression profile than surfaces that promoted fusion.[119]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [119]
Monocyte adhesion, cytokine release, maturation of oocytes, and differentiation of neurons can be significantly affected by different types of plastic and different plastic manufacturing processes.
“It has been shown that monocyte adhesion, cytokine release, maturation of oocytes, and differentiation of neurons, to name just a few, can be significantly affected by different types of plastic and different plastic manufacturing processes (Shen and Horbett, 2001; Brodbeck et al., 2002; Clinchy et al., 2003; Schildknecht et al., 2009).”
From In Vitro research Reproducibility: Keeping up High Standards (2019) · cites this paper as Brodbeck et al., 2002
There is conflicting evidence in the literature regarding the extent of dependence of the foreign body response on biomaterial surface chemistry.
“While the studies by Brodbeck et al. and others [52] suggest a dependence of the FBR on biomaterial surface chemistry, there is conflicting evidence in the literature regarding the extent of this dependence.”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [52]
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- Authors
- Brodbeck, W. G., Nakayama, Y., Matsuda, T., Colton, E., Ziats, N. P., & Anderson, J. M.
- Affiliations
- Case Western Reserve University (US)
- National Cerebral and Cardiovascular Center (JP)
- Kyushu University (JP)
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 18
- Issue
- 6
- Pages
- 311-319
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W1986031245
- Cited by
- 268
- References
- 33
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 7 · 2023: 13 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 13 · 2018: 10 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 17 · 2012: 16
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Keywords
- IL-10, interleukin-8, IL-4, foreign body giant cells, macrophage fusion, monocyte adhesion, surface modification, hydrophilic surfaces, anionic surfaces, cationic surfaces, biocompatibility, biomedical implants, anti-inflammatory response
- MeSH terms
- Biocompatible Materials, Cell Adhesion, Humans, Interleukin-1, Macrophages, Monocytes, Sialoglycoproteins, Time Factors, Interleukin-4, Cytokines, Interleukin-8, Interleukin-10, Reverse Transcriptase Polymerase Chain Reaction, Interleukin 1 Receptor Antagonist Protein
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