The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Canine olfaction as an alternative to analytical instruments for disease diagnosis: understanding ‘dog personality’ to achieve reproducible results
Open accessAbstract
Recent literature has touted the use of canine olfaction as a diagnostic tool for identifying pre-clinical disease status, especially cancer and infection from biological media samples. Studies have shown a wide range of outcomes, ranging from almost perfect discrimination, all the way to essentially random results. This disparity is not likely to be a detection issue; dogs have been shown to have extremely sensitive noses as proven by their use for tracking, bomb detection and search and rescue. However, in contrast to analytical instruments, dogs are subject to boredom, fatigue, hunger and external distractions. These challenges are of particular importance in a clinical environment where task repetition is prized, but not as entertaining for a dog as chasing odours outdoors. The question addressed here is how to exploit the intrinsic sensitivity and simplicity of having a dog simply sniff out disease, in the face of variability in behavior and response.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In recent years, canine olfaction has also been more recognized as a diagnostic tool for identifying pre-clinical disease status, such as diabetes (ketones), different forms of cancer, and infections from biological media samples [37].”
From A One Health Perspective on the Human-Companion Animal Relationship with Emphasis on Zoonotic Aspects. (2020) · cites this paper as [37]
Citations
Cites
Review on ion mobility spectrometry. Part 1: current instrumentation
Cumeras, R., Figueras, E., Davis, C. E., Baumbach, J. I., & Gràcia, I. (2015) · The Analyst · doi:10.1039/c4an01100g · Cited by 459
Research works printed but not linked: 26
- Amann, 2014, The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva, J. Breath Res., 8, 10.1088/1752-7155/8/3/034001 · DOI · Paper page
- de Lacy Costello, 2014, A review of the volatiles from the healthy human body, J. Breath Res., 8, 10.1088/1752-7155/8/1/014001 · DOI · Paper page
- Pleil, 2016, Cellular respiration: replicating in vivo systems biology for in vitro exploration of human exposome, microbiome, and disease pathogenesis biomarkers, J. Breath Res., 10, 10.1088/1752-7155/10/1/010201 · DOI
- Zhu, 2013, Detecting bacterial lung infections: in vivo evaluation of in vitro volatile fingerprints, J. Breath Res., 7, 10.1088/1752-7155/7/1/016003 · DOI
- Filipiak, 2014, Comparative analyses of volatile organic compounds (VOCs) from patients, tumors and transformed cell lines for the validation of lung cancer-derived breath markers, J. Breath Res., 8, 10.1088/1752-7155/8/2/027111 · DOI
- Schroeder, 2015, Volatile S-nitrosothiols and the typical smell of cancer, J. Breath Res., 9, 10.1088/1752-7155/9/1/016010 · DOI
- Kalluri, 2014, Cell culture metabolomics in the diagnosis of lung cancer-the influence of cell culture conditions, J. Breath Res., 8, 10.1088/1752-7155/8/2/027109 · DOI
- Smith, 2014, Mass spectrometry for real-time quantitative breath analysis, J. Breath Res., 8, 10.1088/1752-7155/8/2/027101 · DOI
- Hackner, 2016, Canine scent detection for the diagnosis of lung cancer in a screening-like situation, J. Breath Res., 10, 10.1088/1752-7155/10/4/046003 · DOI
- Williams, 1989, Sniffer dogs in the melanoma clinic?, Lancet, 1, 734, 10.1016/S0140-6736(89)92257-5 · DOI
- McCulloch, 2006, Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers, Integr. Cancer Therapies, 5, 30, 10.1177/1534735405285096 · DOI
- Sonoda, 2011, Colorectal cancer screening with odour material by canine scent detection, Gut, 60, 814, 10.1136/gut.2010.218305 · DOI
- Ehmann, 2012, Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon, Eur. Respiratory J., 39, 669, 10.1183/09031936.00051711 · DOI
- Amundsen, 2014, Can dogs smell lung cancer ? First study using exhaled breath and urine screening in unselected patients with suspected lung cancer, Acta Oncol., 53, 307, 10.3109/0284186X.2013.819996 · DOI
- Elliker, 2014, Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection, BMC Urol., 14, 22, 10.1186/1471-2490-14-22 · DOI
- Jezierski, 2015, Study of the art: canine olfaction used for cancer detection on the basis of breath odour. Perspectives and limitations, J. Breath Res., 9, 10.1088/1752-7155/9/2/027001 · DOI
- Baker, 2003, The central role of receiver operating characteristic (ROC) curves in evaluating tests for the early detection of cancer, J. Natl Cancer Inst., 95, 511, 10.1093/jnci/95.7.511 · DOI
- Brenner, 1990, The effects of sensitivity and specificity of case selection on validity, sample size, precision, and power in hospital-based case-control studies, Am. J. Epidemiol, 132, 181, 10.1093/oxfordjournals.aje.a115630 · DOI
- Phillips, 2003, Detection of lung cancer with volatile markers in the breath, Chest, 123, 2115, 10.1378/chest.123.6.2115 · DOI
- Gasparri, 2016, Volatile signature for the early diagnosis of lung cancer, J. Breath Res., 10, 10.1088/1752-7155/10/1/016007 · DOI
- Aggio, 2016, The use of a gas chromatography-sensor system combined with advanced statistical methods, towards the diagnosis of urological malignancies, J. Breath Res., 10, 10.1088/1752-7155/10/1/017106 · DOI
- Kateb, 2009, Sniffing out cancer using the JPL electronic nose: a pilot study of a novel approach to detection and differentiation of brain cancer, Neuroimage, 47, T5, 10.1016/j.neuroimage.2009.04.015 · DOI
- Bikov, 2015, Established methodological issues in electronic nose research: how far are we from using these instruments in clinical settings of breath analysis?, J. Breath Res., 9, 10.1088/1752-7155/9/3/034001 · DOI
- Buszewski, 2012, Analytical and unconventional methods of cancer detection using odor, Trends Anal. Chem., 38, 1, 10.1016/j.trac.2012.03.019 · DOI
- Hall, 2015, Performance of pugs, German shepherds, and greyhounds (Canis lupus familiaris) on an odor-discrimination task, J. Comparative Psychol., 129, 237, 10.1037/a0039271 · DOI
- Polgar, 2016, A test of canine olfactory capacity: comparing various dog breeds and wolves in a natural detection task, PLoS One, 11, 10.1371/journal.pone.0154087 · DOI
Cited by
Sorted by citations
Overgaauw, P. A. M., Vinke, C. M., van Hagen, M. A. E., & Lipman, L. J. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113789 · Cited by 301
“In recent years, canine olfaction has also been more recognized as a diagnostic tool for identifying pre-clinical disease status, such as diabetes (ketones), different forms of cancer, and infections from biological media samples [37].”
Method
Metadata
- Authors
- Hackner, K., & Pleil, J.
- Affiliations
- Universitätsklinikum Krems (AT)
- Environmental Protection Agency (US)
- Corresponding author
- Hackner, Klaus
- Pleil, Joachim
- Venue
- Journal of Breath Research
- Publisher
- IOP Publishing
- Published
- 2017-01-09
- Volume
- 11
- Issue
- 1
- Pages
- 012001
- ISSN
- 1752-7155 (ISSN-L)
- 1752-7163
- PMC
- PMC6146943
- OpenAlex
- W2570518273
- Cited by
- 46
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 7
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Breath Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Environmental Protection Agency
- Office of Research and Development
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- canine olfaction, disease diagnosis, cancer detection, infection detection, dog personality, reproducibility, odor discrimination, breath analysis
- MeSH terms
- Animals, Chemistry Techniques, Analytical, Dogs, Neoplasms, Personality, Smell, Reproducibility of Results
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
