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Cited by 213Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAutomotive and Human Injury Biomechanics

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Neuropathological Protection after Traumatic Brain Injury in Intact Female Rats Versus Males or Ovariectomized Females

Bramlett, Helen M., Dietrich, W. Dalton·2001·Journal of Neurotrauma
DOI 10.1089/089771501750451811
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Abstract

An important consideration in traumatic brain injury (TBI) in females is the influence of hormones on recovery. Recent studies in both cerebral ischemia and TBI have demonstrated an attenuation in both damage and neurologic recovery following hormonal treatment. However, the ability of endogenous hormone levels to provide neuropathological protection after fluid percussion (FP) brain injury has not been studied. The purpose of this experiment was to determine whether endogenous circulating hormones in the female rat could provide neuroprotection compared to males and ovariectomized female animals. Sixty-four Sprague-Dawley rats underwent a moderate (1.7-2.2 atm) right parasagittal FP injury. Intact females (i.e., nonovariectomized) were subjected to injury either during the proestrous (TBI-FP, n = 18) phase of their cycle or nonproestrous (TBI-FNP, n = 19) phase. A separate group of females were ovariectomized (TBI-OVX, n = 10) 10 days prior to FP injury in order to reduce hormone levels. Male animals were also traumatized (TBI-M, n = 17). Appropriate sham controls (Sham-FP, n = 2; Sham-FNP, n = 2; Sham-OVX, n = 2; Sham-M, n = 2) also underwent all aspects of surgery except for the actual FP injury. All groups were sacrificed 3 days following TBI for analysis. Both intact female groups had significantly (p < 0.05) smaller cortical contusions compared to male animals. In addition to this finding, the TBI-FNP group was significantly (p < 0.04) different from the ovariectomized female animals. Ovariectomized rats had larger areas of damage compared to intact females. The TBI-OVX group's cortical contusion volume was similar to male animals. These results provide evidence for endogenous hormonal histopathological protection following parasagittal FP brain injury. The use of hormone therapy after TBI warrants continued exploration.

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Crossref · 10.1089/089771501750451811

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Citations

Cites

Research works printed but not linked: 7

  1. ALKAYED N.J., 1998, Soc. Neurosci. Abst., 24, 517
  2. DEWITT D.S., 1992, Am. J. Physiol., 263, H1276
  3. GINSBERG M.D., 1997, Am. J. Physiol., 272, H2859
  4. GISCLARD V., 1988, J. Pharmacol. Exp. Ther., 244, 19
  5. GREEN P.S., 1996, Lett., 218, 165
  6. ROOF R.L., 1992, Res. Neurol. Neurosci., 4, 425
  7. SINGER C.A., 1996, Lett., 212, 13

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Metadata

Authors
Bramlett, H. M., & Dietrich, W. D.
Affiliations
University of Miami (US)
ORCID
Venue
Journal of Neurotrauma
Publisher
SAGE Publications
Published
2001-09
Volume
18
Issue
9
Pages
891-900
ISSN
  • 0897-7151 (ISSN-L)
  • 1557-9042
DOI
10.1089/089771501750451811
OpenAlex
W1970991292
Cited by
213
References
59
Citations by year
2026: 7 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 14 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 5 · 2012: 5
FWCI
4.24
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Neurotrauma (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Eli Lilly and Company
  • National Institute of Neurological Disorders and Stroke (NS-30291, P50NS030291)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
Keywords
traumatic brain injury, fluid percussion injury, sex differences, ovariectomy, endogenous hormones, neuroprotection, estrous cycle, proestrus, cortical contusion, female rats, hormone therapy
MeSH terms
Animals, Brain Injuries, Cell Count, Estrogens, Female, Hippocampus, Male, Ovariectomy, Proestrus, Progesterone, Sex Factors, Rats, Sprague-Dawley, Recovery of Function, Rats

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