The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Neuropathological Protection after Traumatic Brain Injury in Intact Female Rats Versus Males or Ovariectomized Females
Abstract
An important consideration in traumatic brain injury (TBI) in females is the influence of hormones on recovery. Recent studies in both cerebral ischemia and TBI have demonstrated an attenuation in both damage and neurologic recovery following hormonal treatment. However, the ability of endogenous hormone levels to provide neuropathological protection after fluid percussion (FP) brain injury has not been studied. The purpose of this experiment was to determine whether endogenous circulating hormones in the female rat could provide neuroprotection compared to males and ovariectomized female animals. Sixty-four Sprague-Dawley rats underwent a moderate (1.7-2.2 atm) right parasagittal FP injury. Intact females (i.e., nonovariectomized) were subjected to injury either during the proestrous (TBI-FP, n = 18) phase of their cycle or nonproestrous (TBI-FNP, n = 19) phase. A separate group of females were ovariectomized (TBI-OVX, n = 10) 10 days prior to FP injury in order to reduce hormone levels. Male animals were also traumatized (TBI-M, n = 17). Appropriate sham controls (Sham-FP, n = 2; Sham-FNP, n = 2; Sham-OVX, n = 2; Sham-M, n = 2) also underwent all aspects of surgery except for the actual FP injury. All groups were sacrificed 3 days following TBI for analysis. Both intact female groups had significantly (p < 0.05) smaller cortical contusions compared to male animals. In addition to this finding, the TBI-FNP group was significantly (p < 0.04) different from the ovariectomized female animals. Ovariectomized rats had larger areas of damage compared to intact females. The TBI-OVX group's cortical contusion volume was similar to male animals. These results provide evidence for endogenous hormonal histopathological protection following parasagittal FP brain injury. The use of hormone therapy after TBI warrants continued exploration.
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“Estrous stage at injury did not influence contusion volumes or behavioral outcomes in female rats. 38,61”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [61]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury
Faden, A. I., Demediuk, P., Panter, S. S., & Vink, R. (1989) · Science · doi:10.1126/science.2567056 · Cited by 1,508
Zilles, K. (1985) · Springer eBooks · doi:10.1007/978-3-642-70573-1 · Cited by 1,066
A fluid percussion model of experimental brain injury in the rat
Dixon, C. E., Lyeth, B. G., Povlishock, J. T., Findling, R. L., Hamm, R. J., Marmarou, A., Young, H. F., & Hayes, R. L. (1987) · Journal of neurosurgery · doi:10.3171/jns.1987.67.1.0110 · Cited by 1,038
Goodman, Y., Bruce‐Keller, A. J., Cheng, B., & Mattson, M. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66051836.x · Cited by 830
Gender-Linked Brain Injury in Experimental Stroke
Alkayed, N. J., Harukuni, I., Kimes, A. S., London, E. D., Traystman, R. J., & Hurn, P. D. (1998) · Stroke · doi:10.1161/01.str.29.1.159 · Cited by 754
The Cortex of the Rat: A Stereotaxic Atlas
Zilles, K. (1985) · Medical Entomology and Zoology · Cited by 657
Roof, R. L., & Hall, E. D. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.367 · Cited by 652
17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro
Behl, C., Widmann, M., Trapp, T., & Holsboer, F. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2647 · Cited by 608
Globus, M. Y. ‐., Alonso, O. F., Dietrich, W. D., Busto, R., & Ginsberg, M. D. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041704.x · Cited by 607
Self-citation
Research works printed but not linked: 7
- ALKAYED N.J., 1998, Soc. Neurosci. Abst., 24, 517
- DEWITT D.S., 1992, Am. J. Physiol., 263, H1276
- GINSBERG M.D., 1997, Am. J. Physiol., 272, H2859
- GISCLARD V., 1988, J. Pharmacol. Exp. Ther., 244, 19
- GREEN P.S., 1996, Lett., 218, 165
- ROOF R.L., 1992, Res. Neurol. Neurosci., 4, 425
- SINGER C.A., 1996, Lett., 212, 13
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Sex bias in neuroscience and biomedical research
Beery, A. K., & Zucker, I. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.002 · Cited by 1,763
Fleminger, S. (2003) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.857 · Cited by 719
Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences
Bramlett, H., & Dietrich, W. (2004) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1097/01.wcb.0000111614.19196.04 · Cited by 622
Self-citationSex Differences in Traumatic Brain Injury: What We Know and What We Should Know
Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533
Lateral Fluid Percussion Brain Injury: A 15-Year Review and Evaluation
Thompson, H. J., Lifshitz, J., Marklund, N., Grady, M. S., Graham, D. I., Hovda, D. A., & McIntosh, T. K. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.42 · Cited by 541
Metadata
- Authors
- Bramlett, H. M., & Dietrich, W. D.
- Affiliations
- University of Miami (US)
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2001-09
- Volume
- 18
- Issue
- 9
- Pages
- 891-900
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W1970991292
- Cited by
- 213
- References
- 59
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 14 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 5 · 2012: 5
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurotrauma (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- National Institute of Neurological Disorders and Stroke (NS-30291, P50NS030291)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
- Keywords
- traumatic brain injury, fluid percussion injury, sex differences, ovariectomy, endogenous hormones, neuroprotection, estrous cycle, proestrus, cortical contusion, female rats, hormone therapy
- MeSH terms
- Animals, Brain Injuries, Cell Count, Estrogens, Female, Hippocampus, Male, Ovariectomy, Proestrus, Progesterone, Sex Factors, Rats, Sprague-Dawley, Recovery of Function, Rats
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