Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease

In the citing paper

“Therefore, CeH represents a major false negative result of the 'reflex TSH strategy,' which is a widely accepted method for screening thyroid function by a first-line TSH measurement [4-7].”

In the citing paper

“over 95% of rigorously screened individuals without thyroid disease or autoantibodies have TSH concentrations below 2.5 mIU/L [11].”

In the citing paper

“The diagnosis of hypothyroidism is in the routine clinical setting based on a TSH screening strategy (Baloch et al., 2003;Feldt-Rasmussen and Klose, 2020), but this strategy is useless in case of central hypothyroidism where an inappropriately low/normal serum TSH concentration is seen (Feldt-Rasmussen et al., 2018;Persani et al., 2018).”

In the citing paper

“Furthermore, the biochemical hormonal changes of central hypothyroidism are not very different from those of critical illness and other situations of non-thyroidal illness (Baloch et al., 2003;Feldt-Rasmussen, 2020;Peeters and Boelen, 2021; Van den Berghe, 2014) (Fig. 3).”

In the citing paper

“Finally, estimates of free T4 concentrations are widely measured on different platforms in Clinical Biochemical Laboratories, with the unfortunate result of a huge Recovery from transient thyroiditis Isolated hypothyroxinaemia interlaboratory variability (Baloch et al., 2003;Esfandiari and Papaleontiou, 2017;Feldt-Rasmussen, 2020;Welsh and Soldin, 2016).”

In the citing paper

“Since fT4 reflects the unbound biologically active form of T4, measurement of fT4 is preferred to total T4 (98).”