The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tissue Engineering of Ligaments: A Comparison of Bone Marrow Stromal Cells, Anterior Cruciate Ligament, and Skin Fibroblasts as Cell Source
Abstract
Anterior cruciate ligament (ACL) reconstruction surgery still has important problems to overcome, such as "donor site morbidity" and the limited choice of grafts in revision surgery. Tissue engineering of ligaments may provide a solution for these problems. Little is known about the optimal cell source for tissue engineering of ligaments. The aim of this study is to determine the optimal cell source for tissue engineering of the anterior cruciate ligament. Bone marrow stromal cells (BMSCs), ACL, and skin fibroblasts were seeded onto a resorbable suture material [poly(L-lactide/glycolide) multifilaments] at five different seeding densities, and cultured for up to 12 days. All cell types tested attached to the suture material, proliferated, and synthesized extracellular matrix rich in collagen type I. On day 12 the scaffolds seeded with BMSCs showed the highest DNA content (p < 0.01) and the highest collagen production (p < 0.05 for the two highest seeding densities). Scaffolds seeded with ACL fibroblasts showed the lowest DNA content and collagen production. Accordingly, BMSCs appear to be the most suitable cells for further study and development of tissue-engineered ligament.
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Citations
Cites
Development of fibroblast‐seeded ligament analogs for ACL reconstruction
Dunn, M. G., Liesch, J. B., Tiku, M. L., & Zawadsky, J. P. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820291107 · Cited by 206
Cited by
Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm
Yang, G., Rothrauff, B. B., & Tuan, R. S. (2013) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.21041 · Cited by 469
Sahoo, S., Ouyang, H., Goh, J. C.-H., Tay, T. E., & Toh, S. L. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.91 · Cited by 332
Sahoo, S., Toh, S. L., & Goh, J. C. H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.004 · Cited by 329
Fan, H., Liu, H., Wong, E. J. W., Toh, S. L., & Goh, J. C. H. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.012 · Cited by 209
Cell delivery therapeutics for musculoskeletal regeneration☆
Nöth, U., Rackwitz, L., Steinert, A. F., & Tuan, R. S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.04.004 · Cited by 119
Metadata
- Authors
- Van Eijk, F., Saris, D. B. F., Riesle, J., Willems, W. J., van Blitterswijk, C. A., Verbout, A. J., & Dhert, W. J. A.
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 2004-05
- Volume
- 10
- Issue
- 5-6
- Pages
- 893-903
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W2154177449
- Cited by
- 170
- References
- 1
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tissue Engineering of Ligaments: A Comparison of Bone Marrow Stromal Cells, Anterior Cruciate Ligament, and Skin Fibroblasts as Cell Source. https://app.cochat.ai/papers/10.1089/1076327041348428
- The paper
- Van Eijk, F., Saris, D. B. F., Riesle, J., Willems, W. J., van Blitterswijk, C. A., Verbout, A. J., & Dhert, W. J. A. (2004). Tissue Engineering of Ligaments: A Comparison of Bone Marrow Stromal Cells, Anterior Cruciate Ligament, and Skin Fibroblasts as Cell Source. Tissue Engineering. https://doi.org/10.1089/1076327041348428
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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