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Cited by 193Natural Antidiabetic Agents StudiesSeaweed-derived Bioactive CompoundsDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Role of Spirulina in the Control of Glycemia and Lipidemia in Type 2 Diabetes Mellitus

Parikh, Panam, Mani, Uliyar, Iyer, Uma·2001·Journal of Medicinal Food
DOI 10.1089/10966200152744463
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Abstract

Spirulina, with its high concentration of functional nutrients, is emerging as an important therapeutic food. This study aimed to evaluate the hypoglycemic and hypolipidemic role of Spirulina. Twenty-five subjects with type 2 diabetes mellitus were randomly assigned to receive Spirulina (study group) or to form the control group. At baseline, the control and study groups were matched for various variables. The efficacy of Spirulina supplementation (2 g/day for 2 months) was determined using the preintervention and postintervention blood glucose levels, glycosylated hemoglobin (HbA(1c)) levels, and lipid profiles of the diabetic subjects. Two-month supplementation with Spirulina resulted in an appreciable lowering of fasting blood glucose and postprandial blood glucose levels. A significant reduction in the HbA(1c) level was also observed, indicating improved long-term glucose regulation. With regard to lipids, triglyceride levels were significantly lowered. Total cholesterol (TC) and its fraction, low-density lipoprotein cholesterol (LDL-C), exhibited a fall coupled with a marginal increase in the level of high-density lipoprotein cholesterol (HDL-C). As a result, a significant reduction in the atherogenic indices, TC:HDL-C and LDL-C: HDL-C, was observed. The level of apolipoprotein B registered a significant fall together with a significant increment in the level of apolipoprotein A1. Therefore, a significant and favorable increase in the ratio of A1:B was also noted. These findings suggest the beneficial effect of Spirulina supplementation in controlling blood glucose levels and in improving the lipid profile of subjects with type 2 diabetes mellitus.

Overview

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Crossref · 10.1089/10966200152744463

Cites

22 of 22 references verified0 citation errors · 0 not checkable

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Citations

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Show all 21 references

Research works printed but not linked: 6

  1. Wolffenbuttael BHR, 1999, Med Sci Monit, 5, 1013
  2. George P, 2000, J Clin Basic Cardiol, 3, 159
  3. Mani UV, 2000, J Food Sci Technol, 37, 642
  4. Iyer UM, 1999, Int J Diab Dev Countries, 19, 17
  5. Iyer UM, 1999, Int J Diab Dev Countries, 19, 108
  6. Shamoon H, 1996, Drug Benefit Trends, 10

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Related

Metadata

Authors
Parikh, P., Mani, U., & Iyer, U.
Affiliations
Maharaja Sayajirao University of Baroda (IN)
ORCID
Parikh, Panam
Venue
Journal of Medicinal Food
Publisher
SAGE Publications
Published
2001-12
Volume
4
Issue
4
Pages
193-199
ISSN
  • 1096-620X (ISSN-L)
  • 1557-7600
DOI
10.1089/10966200152744463
OpenAlex
W1594930126
Cited by
193
References
21
Citations by year
2026: 4 · 2025: 9 · 2024: 15 · 2023: 14 · 2022: 13 · 2021: 17 · 2020: 14 · 2019: 8 · 2018: 15 · 2017: 8 · 2016: 11 · 2015: 13 · 2014: 7 · 2013: 9 · 2012: 6
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Medicinal Food (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
Spirulina, type 2 diabetes, glycemic control, hypoglycemic effect, hypolipidemic effect, lipid profile, HbA1c, triglycerides, LDL cholesterol, HDL cholesterol, apolipoprotein B, apolipoprotein A-I, functional food supplementation

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