Cited by 290Palliative Care and End-of-Life IssuesPalliative and Oncologic CareFrailty in Older Adults

Dying Trajectory in the Last Year of Life: Does Cancer Trajectory Fit Other Diseases?

Teno, Joan M., Weitzen, Sherry, Fennell, Mary L., Mor, Vincent·2001·Journal of Palliative Medicine

Abstract

PURPOSE: To examine differences in the pattern of functional decline among persons dying of cancer and other leading noncancer causes of death. DESIGN: Mortality followback survey of next of kin listed on death certificate. SETTING: Probability sample of all deaths in the United States. PARTICIPANTS: Next of kin for 3,614 decedents that represented 914,335 deaths. MEASUREMENTS: Days of difficulty with activities of daily living and mobility in the last year of life. RESULTS: Relative to other decedents, patients with cancer experienced an increased rate of functional impairment beginning as late as 5 months prior to death. For example, only 13.9% of patients with cancer had difficulty getting out of bed or a chair 1-year prior to death. This increased from 22.2% to 63.0% in the last five months of life. In contrast, decedents from other diseases had higher rates of functional impairment 1 year prior to death (approximately 35% had difficulty getting out of bed or chair) and they manifested a more gradual increase in the level of functional decline (approximately 50% had difficulty getting out of bed). Precipitous functional decline was associated with hospice involvement and dying at home. CONCLUSION: Persons dying of cancer experienced sharp functional decline in the last months of life whereas other decedents' have a more gradual decline. The more precipitous functional decline was associated with hospice involvement and dying at home.

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Crossref · 10.1089/109662101753381593

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  • When controlling for potential covariates, subjective sleep quality (PSQI) and insomnia status were predictive of the influenza antibody response.

    “When controlling for potential covariates, subjective sleep quality (assessed by the PSQI) and insomnia status were predictive of the influenza antibody response”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [536]

  • The vaccination response to influenza did not differ between 133 healthy college students with or without insomnia, although the insomnia group had overall lower antibody amounts pre- and post-vaccination.

    “the vaccination response to influenza did not differ between 133 healthy college students with or without insomnia (based on DSM-V criteria), although the insomnia group had overall lower antibody amounts pre- and post-vaccination”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [536]

  • Abnormalities reported for basal immune and inflammatory markers in insomnia disorder may underlie inadequate influenza vaccine responses.

    “Such abnormalities reported for basal immune and inflammatory markers in insomnia disorder may underlie inadequate influenza vaccine responses as recently reported”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [536]

  • Both subjective sleep quality and insomnia status may attenuate immunity to the influenza virus.

    “which led the authors to suggest that both may attenuate immunity to the influenza virus”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [536]

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Authors
Teno, J. M., Weitzen, S., Fennell, M. L., & Mor, V.
Affiliations
Brown University (US)
Venue
Journal of Palliative Medicine
Published
2001-12
Volume
4
Issue
4
Pages
457-464
ISSN
  • 1096-6218 (ISSN-L)
  • 1557-7740
OpenAlex
W2046867396
Cited by
290
References
22
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 11 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 18 · 2018: 14 · 2017: 14 · 2016: 16 · 2015: 10 · 2014: 12 · 2013: 10 · 2012: 18
FWCI
8.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Palliative Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Robert Wood Johnson Foundation
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords
functional decline, last year of life, cancer mortality, activities of daily living, mobility impairment, hospice care, home death, next of kin
MeSH terms
Activities of Daily Living, Data Collection, Death, Death Certificates, Diabetes Mellitus, Heart Failure, Humans, Neoplasms, Prognosis, United States, Hospice Care, Disease Progression, Stroke, Pulmonary Disease, Chronic Obstructive

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