Comparison of Glucose Concentration in Interstitial Fluid, and Capillary and Venous Blood During Rapid Changes in Blood Glucose Levels
Abstract
The relationship between glucose concentrations in interstitial fluid (ISF) and blood has generated great interest due to its importance in minimally invasive and noninvasive techniques for measuring blood glucose. The relationship between glucose levels in dermal ISF, and capillary and venous blood was studied with the dermal ISF samples obtained using the suction blister technique. The study was conducted with intensely managed diabetics whose blood glucose levels were manipulated so as to induce rapid changes in blood glucose levels. Glucose levels in the three compartments exhibited high correlations both when individual subjects were considered separately and when data from all subjects were combined. No significant time lag during glucose excursions was observed among the ISF, and capillary and venous glucose levels.
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ISF composition leads to reliable correlations between blood and ISF concentrations of many analytes, including electrolytes, metabolites, and proteins.
“This function, and the associated ISF composition, lead to reliable correlations between the blood and ISF concentrations of many analytes, including electrolytes (e.g., sodium, phosphate, magnesium, potassium or calcium), metabolites (e.g., glucose, alcohol, lactate or cortisol) and proteins65-69.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [65]
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Blood glucose measurement by using hollow optical fiber-based attenuated total reflection probe
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Clinical Evaluation of a Photonic Crystal Sensor for Glucose Monitoring in Urine
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Assessing and Advancing Technology for the Noninvasive Measurement of Clinical Glucose
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- Authors
- Thennadil, S. N., Rennert, J. L., Wenzel, B. J., Hazen, K. H., Ruchti, T. L., & Block, M. B.
- Affiliations
- Instrumentation Metrics, Inc., Chandler, Arizona; sthennadil@imetricsinc.com
- Instrumentation Metrics, Inc., Chandler, Arizona
- Radiant Research (United States) (US)
- Venue
- Diabetes Technology & Therapeutics
- Publisher
- SAGE Publications
- Published
- 2001-09
- Volume
- 3
- Issue
- 3
- Pages
- 357-365
- ISSN
- 1520-9156 (ISSN-L)
- 1557-8593
- OpenAlex
- W2145770174
- Cited by
- 166
- References
- 19
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 7 · 2023: 12 · 2022: 11 · 2021: 13 · 2020: 11 · 2019: 10 · 2018: 11 · 2017: 7 · 2016: 8 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Technology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- interstitial glucose, capillary blood glucose, venous blood glucose, glycemic excursions, non-invasive glucose monitoring, diabetes mellitus, time delay
- MeSH terms
- Adult, Blood Glucose, Capillaries, Extracellular Space, Female, Glucose, Humans, Male, Regional Blood Flow, Skin, Veins, Spectroscopy, Near-Infrared
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