Cited by 166Diabetes Management and ResearchSkin Diseases and DiabetesClinical Laboratory Practices and Quality Control

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Comparison of Glucose Concentration in Interstitial Fluid, and Capillary and Venous Blood During Rapid Changes in Blood Glucose Levels

Thennadil, Suresh N., Rennert, Jessica L., Wenzel, Brian J., Hazen, Kevin H., Ruchti, Timothy L., Block, Marshall B.·2001·Diabetes Technology & Therapeutics

DOI 10.1089/15209150152607132

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Abstract

The relationship between glucose concentrations in interstitial fluid (ISF) and blood has generated great interest due to its importance in minimally invasive and noninvasive techniques for measuring blood glucose. The relationship between glucose levels in dermal ISF, and capillary and venous blood was studied with the dermal ISF samples obtained using the suction blister technique. The study was conducted with intensely managed diabetics whose blood glucose levels were manipulated so as to induce rapid changes in blood glucose levels. Glucose levels in the three compartments exhibited high correlations both when individual subjects were considered separately and when data from all subjects were combined. No significant time lag during glucose excursions was observed among the ISF, and capillary and venous glucose levels.

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Authors: Thennadil, S. N., Rennert, J. L., Wenzel, B. J., Hazen, K. H., Ruchti, T. L., & Block, M. B.
Affiliations: Instrumentation Metrics, Inc., Chandler, Arizona; sthennadil@imetricsinc.com
Instrumentation Metrics, Inc., Chandler, Arizona
Radiant Research (United States) (US)
ORCID: Thennadil, Suresh N.
Ruchti, Timothy L.
Venue: Diabetes Technology & Therapeutics
Publisher: SAGE Publications
Published: 2001-09
Volume: 3
Issue: 3
Pages: 357-365
ISSN: 1520-9156 (ISSN-L)
1557-8593
DOI: 10.1089/15209150152607132
OpenAlex: W2145770174
Cited by: 166
References: 19
Citations by year: 2026: 7 · 2025: 9 · 2024: 7 · 2023: 12 · 2022: 11 · 2021: 13 · 2020: 11 · 2019: 10 · 2018: 11 · 2017: 7 · 2016: 8 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 5
FWCI: 3.68
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Diabetes Technology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Funders: Israel Science Foundation
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Keywords: interstitial glucose, capillary blood glucose, venous blood glucose, glycemic excursions, non-invasive glucose monitoring, diabetes mellitus, time delay
MeSH terms: Adult, Blood Glucose, Capillaries, Extracellular Space, Female, Glucose, Humans, Male, Regional Blood Flow, Skin, Veins, Spectroscopy, Near-Infrared

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Comparison of Glucose Concentration in Interstitial Fluid, and Capillary and Venous Blood During Rapid Changes in Blood Glucose Levels

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