The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
A Broadly Neutralizing Human Monoclonal Antibody against gp41 of Human Immunodeficiency Virus Type 1
Abstract
We have established a hybridoma clone, designated 2F5, secreting a neutralizing human monoclonal antibody (MAb) specific for gp41 of human immunodeficiency virus type 1 (HIV-1). The epitope of MAb 2F5 was mapped to amino acid sequence Glu-Leu-Asp-Lys-Trp-Ala on the ectodomain of gp41. In this study different in vitro test systems were used to characterize the neutralizing properties of MAb 2F5. In syncytium inhibition assays, fusion inhibition experiments, and neutralization assays on different HIV-susceptible cells (H9, U937, and peripheral blood mononuclear cells) MAb 2F5 showed broad-spectrum neutralizing capacity against HIV-1 laboratory isolates IIIB, MN, RF, and SF2. In addition, primary isolates from AIDS patients were also neutralized.
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A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
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Self-citationA simple method of estimating fifty per cent end-points.
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Cited by
Trkola, A., Purtscher, M., Muster, T., Ballaun, C., Buchacher, A., Sullivan, N., Srinivasan, K., Sodroski, J., Moore, J. P., & Katinger, H. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.1100-1108.1996 · Cited by 1,114
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Self-citationFunctional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein
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Metadata
- Authors
- PURTSCHER, M., TRKOLA, A., GRUBER, G., BUCHACHER, A., PREDL, R., STEINDL, F., TAUER, C., BERGER, R., BARRETT, N., JUNGBAUER, A., & KATINGER, H.
- Venue
- AIDS Research and Human Retroviruses
- Publisher
- SAGE Publications
- Published
- 1994-12
- Volume
- 10
- Issue
- 12
- Pages
- 1651-1658
- ISSN
- 0889-2229 (ISSN-L)
- 1931-8405
- OpenAlex
- W2012362118
- Cited by
- 347
- References
- 25
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- PURTSCHER, M., TRKOLA, A., GRUBER, G., BUCHACHER, A., PREDL, R., STEINDL, F., TAUER, C., BERGER, R., BARRETT, N., JUNGBAUER, A., & KATINGER, H. (1994). A Broadly Neutralizing Human Monoclonal Antibody against gp41 of Human Immunodeficiency Virus Type 1. AIDS Research and Human Retroviruses. https://doi.org/10.1089/aid.1994.10.1651
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
