The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration
Open accessAbstract
In normal brain, neurons, astrocytes, and oligodendrocytes, the most abundant and active cells express pannexins and connexins, protein subunits of two families forming membrane channels. Most available evidence indicates that in mammals endogenously expressed pannexins form only hemichannels and connexins form both gap junction channels and hemichannels. Whereas gap junction channels connect the cytoplasm of contacting cells and coordinate electric and metabolic activity, hemichannels communicate the intra- and extracellular compartments and serve as a diffusional pathway for ions and small molecules. A subthreshold stimulation by acute pathological threatening conditions (e.g., global ischemia subthreshold for cell death) enhances neuronal Cx36 and glial Cx43 hemichannel activity, favoring ATP release and generation of preconditioning. If the stimulus is sufficiently deleterious, microglia become overactivated and release bioactive molecules that increase the activity of hemichannels and reduce gap junctional communication in astroglial networks, depriving neurons of astrocytic protective functions, and further reducing neuronal viability. Continuous glial activation triggered by low levels of anomalous proteins expressed in several neurodegenerative diseases induce glial hemichannel and gap junction channel disorders similar to those of acute inflammatory responses triggered by ischemia or infectious diseases. These changes are likely to occur in diverse cell types of the CNS and contribute to neurodegeneration during inflammatory process.
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Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Intercellular Ca2+Waves: Mechanisms and Function
Leybaert, L., & Sanderson, M. J. (2012) · Physiological Reviews · doi:10.1152/physrev.00029.2011 · Cited by 331
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Connexins: Key Mediators of Endocrine Function
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Metadata
- Authors
- Orellana, J. A., Sáez, P. J., Shoji, K. F., Schalper, K. A., Palacios–Prado, N., Velarde, V., Giaume, C., Bennett, M. V. L., & Sáez, J. C.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2009-02
- Volume
- 11
- Issue
- 2
- Pages
- 369-399
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2020025443
- Cited by
- 223
- References
- 27
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration. https://app.cochat.ai/papers/10.1089/ars.2008.2130
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- Orellana, J. A., Sáez, P. J., Shoji, K. F., Schalper, K. A., Palacios–Prado, N., Velarde, V., Giaume, C., Bennett, M. V. L., & Sáez, J. C. (2009). Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2008.2130
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