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The Role of Energy Metabolism Dysfunction and Oxidative Stress in Schizophrenia Revealed by Proteomics
Abstract
Schizophrenia is a psychiatric illness that affects approximately 30 million people worldwide. Converging lines of evidence suggest that mitochondrial function may be compromised in this disorder, and this can lead to perturbations in calcium buffering, oxidative phosphorylation, increased production of reactive oxygen species, and apoptotic factors, which can, in turn, affect neuronal processes such as neurotransmitter synthesis and synaptic plasticity. Proteomics studies in brain and peripheral tissues of schizophrenia patients have provided considerable evidence and identified biomarker fingerprints corresponding to such pathways. Here we review the results of these studies with a focus on the biomarker pattern depicting alterations in energy metabolism and oxidative stress in this debilitating illness. Antioxid. Redox Signal. 15, 2067–2079.
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“GSH levels have been shown to be lower in chronic schizophrenia, as measured in the CSF and post-mortem brain, and by MRS-based in vivo imaging 41,42 and the GSH system enzymes glutathione peroxidase (GPX) and glutathione reductase (GR) are also dysregulated 36 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [42]
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Metadata
- Authors
- Martins-de-Souza, D., Harris, L. W., Guest, P. C., & Bahn, S.
- Affiliations
- University of Cambridge
- University of Cambridge (GB)
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-10
- Volume
- 15
- Issue
- 7
- Pages
- 2067-2079
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2017966444
- Cited by
- 134
- References
- 91
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 12 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 13
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stanley Medical Research Institute
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- schizophrenia, oxidative stress, mitochondrial dysfunction, reactive oxygen species, apoptosis, biomarkers, proteomics, brain, peripheral tissues, calcium buffering, oxidative phosphorylation, synaptic plasticity
- MeSH terms
- Animals, Energy Metabolism, Humans, Schizophrenia, Oxidative Stress, Proteome, Lipid Metabolism
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