Cited by 134Schizophrenia research and treatmentMitochondrial Function and PathologyAmino Acid Enzymes and Metabolism

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The Role of Energy Metabolism Dysfunction and Oxidative Stress in Schizophrenia Revealed by Proteomics

Martins-de-Souza, Daniel, Harris, Laura W., Guest, Paul C., Bahn, Sabine·2011·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3459

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Abstract

Schizophrenia is a psychiatric illness that affects approximately 30 million people worldwide. Converging lines of evidence suggest that mitochondrial function may be compromised in this disorder, and this can lead to perturbations in calcium buffering, oxidative phosphorylation, increased production of reactive oxygen species, and apoptotic factors, which can, in turn, affect neuronal processes such as neurotransmitter synthesis and synaptic plasticity. Proteomics studies in brain and peripheral tissues of schizophrenia patients have provided considerable evidence and identified biomarker fingerprints corresponding to such pathways. Here we review the results of these studies with a focus on the biomarker pattern depicting alterations in energy metabolism and oxidative stress in this debilitating illness. Antioxid. Redox Signal. 15, 2067–2079.

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Authors: Martins-de-Souza, D., Harris, L. W., Guest, P. C., & Bahn, S.
Affiliations: University of Cambridge
University of Cambridge (GB)
ORCID: Harris, Laura W.
Guest, Paul C.
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2011-10
Volume: 15
Issue: 7
Pages: 2067-2079
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3459
OpenAlex: W2017966444
Cited by: 134
References: 91
Citations by year: 2026: 6 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 12 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 13
FWCI: 1.39
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: Stanley Medical Research Institute
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: schizophrenia, oxidative stress, mitochondrial dysfunction, reactive oxygen species, apoptosis, biomarkers, proteomics, brain, peripheral tissues, calcium buffering, oxidative phosphorylation, synaptic plasticity
MeSH terms: Animals, Energy Metabolism, Humans, Schizophrenia, Oxidative Stress, Proteome, Lipid Metabolism

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The Role of Energy Metabolism Dysfunction and Oxidative Stress in Schizophrenia Revealed by Proteomics

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