The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Cooperative Roles of Inflammation and Oxidative Stress in the Pathogenesis of Hypertension
Open accessAbstract
SIGNIFICANCE: Innate and adaptive immunity play fundamental roles in the development of hypertension and its complications. As effectors of the cell-mediated immune response, myeloid cells and T lymphocytes protect the host organism from infection by attacking foreign intruders with bursts of reactive oxygen species (ROS). RECENT ADVANCES: While these ROS may help to preserve the vascular tone and thereby protect against circulatory collapse in the face of overwhelming infection, aberrant elaboration of ROS triggered by immune cells in the absence of a hemodynamic insult can lead to pathologic increases in blood pressure. Conversely, misdirected oxidative stress in cardiovascular control organs, including the vasculature, the kidney, and the nervous system potentiates inflammatory responses, augmenting blood pressure elevation and inciting target organ damage. CRITICAL ISSUES: Inflammation and oxidative stress thereby act as cooperative and synergistic partners in the pathogenesis of hypertension. FUTURE DIRECTIONS: Pharmacologic interventions for hypertensive patients will need to exploit this robust bidirectional relationship between ROS generation and immune activation in cardiovascular control organs to maximize therapeutic benefit, while limiting off-target side effects.
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Cites
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
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Exploring the full spectrum of macrophage activation
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Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
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Modulation of Blood Pressure by Central Melanocortinergic Pathways
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T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
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Cited by
Endothelial Dysfunction and Hypertension
Konukoglu, D., & Uzun, H. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2016_90 · Cited by 594
Buford, T. W. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.007 · Cited by 561
Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Karbach, S. H., Schönfelder, T., Brandão, I., Wilms, E., Hörmann, N., Jäckel, S., Schüler, R., Finger, S., Knorr, M., Lagrange, J., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003698 · Cited by 378
Frąk, W., Wojtasińska, A., Lisińska, W., Młynarska, E., Franczyk, B., & Rysz, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081938 · Cited by 303
Serban, C., Sahebkar, A., Ursoniu, S., Andrica, F., & Banach, M. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000585 · Cited by 133
Metadata
- Authors
- Crowley, S. D.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2014-01
- Volume
- 20
- Issue
- 1
- Pages
- 102-120
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2312275660
- Cited by
- 191
- References
- 11
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- green
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