The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Loneliness, Social Isolation, and Cardiovascular Health
Open accessAbstract
SIGNIFICANCE: Social and demographic changes have led to an increased prevalence of loneliness and social isolation in modern society. Recent Advances: Population-based studies have demonstrated that both objective social isolation and the perception of social isolation (loneliness) are correlated with a higher risk of mortality and that both are clearly risk factors for cardiovascular disease (CVD). Lonely individuals have increased peripheral vascular resistance and elevated blood pressure. Socially isolated animals develop more atherosclerosis than those housed in groups. CRITICAL ISSUES: Molecular mechanisms responsible for the increased cardiovascular risk are poorly understood. In recent reports, loneliness and social stress were associated with activation of the hypothalamic-pituitary-adrenocortical axis and the sympathetic nervous system. Repeated and chronic social stress leads to glucocorticoid resistance, enhanced myelopoiesis, upregulated proinflammatory gene expression, and oxidative stress. However, the causal role of these mechanisms in the development of loneliness-associated CVD remains unclear. FUTURE DIRECTIONS: Elucidation of the molecular mechanisms of how CVD is induced by loneliness and social isolation requires additional studies. Understanding of the pathomechanisms is essential for the development of therapeutic strategies to prevent the detrimental effects of social stress on health. Antioxid. Redox Signal. 28, 837-851.
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Cites
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Cited by
Guzik, T. J., Mohiddin, S. A., Dimarco, A., Patel, V., Savvatis, K., Marelli-Berg, F. M., Madhur, M. S., Tomaszewski, M., Maffia, P., D’Acquisto, F., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa106 · Cited by 1,440
Loneliness and social isolation during the COVID-19 pandemic
Hwang, T.-J., Rabheru, K., Peisah, C., Reichman, W., & Ikeda, M. (2020) · International Psychogeriatrics · doi:10.1017/s1041610220000988 · Cited by 1,044
Transportation noise pollution and cardiovascular disease
Münzel, T., Sørensen, M., & Daiber, A. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00532-5 · Cited by 572
Loneliness in the Modern Age: An Evolutionary Theory of Loneliness (ETL)
Cacioppo, J. T., & Cacioppo, S. (2018) · Advances in Experimental Social Psychology · doi:10.1016/bs.aesp.2018.03.003 · Cited by 481
Lim, M. H., Eres, R., & Vasan, S. (2020) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-020-01889-7 · Cited by 438
Metadata
- Authors
- Xia, N., & Li, H.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2018-03-20
- Volume
- 28
- Issue
- 9
- Pages
- 837-851
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2754400581
- Cited by
- 493
- References
- 151
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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