The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Transcriptional Regulation by Nrf2
Open accessAbstract
SIGNIFICANCE: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health. Recent Advances: Nrf2 regulates the transcription of components of the glutathione and thioredoxin antioxidant systems, as well as enzymes involved in phase I and phase II detoxification of exogenous and endogenous products, NADPH regeneration, and heme metabolism. It therefore represents a crucial regulator of the cellular defense mechanisms against xenobiotic and oxidative stress. In addition to antioxidant responses, Nrf2 is involved in other cellular processes, such as autophagy, intermediary metabolism, stem cell quiescence, and unfolded protein response. Given the wide range of processes that Nrf2 controls, its activity is tightly regulated at multiple levels. Here, we review the different modes of regulation of Nrf2 activity and the current knowledge of Nrf2-mediated transcriptional control. CRITICAL ISSUES: It is now clear that Nrf2 lies at the center of a complex regulatory network. A full comprehension of the Nrf2 program will require an integrated consideration of all the different factors determining Nrf2 activity. FUTURE DIRECTIONS: Additional computational and experimental studies are needed to obtain a more dynamic global view of Nrf2-mediated gene regulation. In particular, studies comparing how the Nrf2-dependent network changes from a physiological to a pathological condition can provide insight into mechanisms of disease and instruct new treatment strategies.
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Cites
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“Some of these binding sites could be located in the promoter region of long non-coding RNAs (lncRNAs), which were beginning to be annotated when Nrf2 binding sites were first profiled (44).”
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Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
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“Together with the ‘‘default Nrf2 program,’’ Nrf2 selectively activates other genes that are specific to the cell type and the nature of the inducing agent (2, 13, 82, 89, 107, 164, 182, 188).”
Background
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The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
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Exercise-induced oxidative stress: Friend or foe?
Powers, S. K., Deminice, R., Ozdemir, M., Yoshihara, T., Bomkamp, M. P., & Hyatt, H. (2020) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.04.001 · Cited by 655
Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541
The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
Yu, C., & Xiao, J.-H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6635460 · Cited by 537
Nrf2/Keap1/ARE signaling: Towards specific regulation
Ulasov, A. V., Rosenkranz, A. A., Georgiev, G. P., & Sobolev, A. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2021.120111 · Cited by 508
Metadata
- Authors
- Tonelli, C., Chio, I. I. C., & Tuveson, D. A.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2018-12-10
- Volume
- 29
- Issue
- 17
- Pages
- 1727-1745
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2753995352
- Cited by
- 2,192
- References
- 39
- FWCI
- 28.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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