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Cited by 118Attention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional DevelopmentBehavioral and Psychological Studies

Methylphenidate Effects on Functional Outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)

Abikoff, Howard B., Vitiello, Benedetto, Riddle, Mark A., Cunningham, Charles, Greenhill, Laurence L., Swanson, James M., Chuang, Shirley Z., Davies, Mark +11 more·2007·Journal of Child and Adolescent Psychopharmacology
DOI 10.1089/cap.2007.0068
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Abstract

OBJECTIVE: The purpose of this study was to examine the effects of methylphenidate (MPH) on functional outcomes, including children's social skills, classroom behavior, emotional status, and parenting stress, during the 4-week, double-blind placebo controlled phase of the Preschoolers with Attention Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS). METHODS: A total of 114 preschoolers who had improved with acute MPH treatment, were randomized to their best MPH dose (M = 14.22 mg/day; n = 63) or placebo (PL; n = 51). Assessments included the Clinical Global Impression-Severity (CGI-S), parent and teacher versions of the Strengths and Weaknesses of ADHD-Symptoms and Normal Behaviors (SWAN), Social Competence Scale (SCS), Social Skills Rating System (SSRS), and Early Childhood Inventory (ECI), and Parenting Stress Index (PSI). RESULTS: Medication effects varied by informant and outcome measure. Parent measures and teacher SWAN scores did not differentially improve with MPH. Parent-rated depression (p < 0.02) and dysthymia (p < 0.001) on the ECI worsened with MPH, but scores were not in the clinical range. Significant medication effects were found on clinician CGI-S (p < 0.0001) and teacher social competence ratings (SCS, p < 0.03). CONCLUSIONS: Preschoolers with ADHD treated with MPH for 4 weeks improve in some aspects of functioning. Additional improvements might require longer treatment, higher doses, and/or intensive behavioral treatment in combination with medication.

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Crossref · 10.1089/cap.2007.0068

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  • Data suggest greater sensitivity to emotionality following prescription of stimulants or atomoxetine in younger age groups.

    “there are also data to inform relative risks of prescription of stimulants and atomoxetine in younger age groups [6, 74]—which suggest greater sensitivity to emotionality following prescription of either drug”

    From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [6]

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Authors
Abikoff, H. B., Vitiello, B., Riddle, M. A., Cunningham, C., Greenhill, L. L., Swanson, J. M., Chuang, S. Z., Davies, M., Kastelic, E., Wigal, S. B., Evans, L., Ghuman, J. K., Kollins, S. H., McCracken, J. T., McGough, J. J., Murray, D. W., Posner, K., Skrobala, A. M., & Wigal, T.
Affiliations
  • New York University (US)
  • Suburban Hospital (US)
  • Johns Hopkins University (US)
  • McMaster University (CA)
  • New York State Psychiatric Institute (US)
  • University of California, Irvine (US)
  • University of Arizona (US)
  • Duke Medical Center (US)
  • University of California, Los Angeles (US)
ORCID
Venue
Journal of Child and Adolescent Psychopharmacology
Publisher
SAGE Publications
Published
2007-10
Volume
17
Issue
5
Pages
581-592
ISSN
  • 1044-5463 (ISSN-L)
  • 1557-8992
DOI
10.1089/cap.2007.0068
OpenAlex
W2060334009
Cited by
118
References
44
Citations by year
2025: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 10 · 2016: 42 · 2015: 5 · 2014: 9 · 2013: 4 · 2012: 7
FWCI
2.62
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Child and Adolescent Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders
National Institute of Mental Health (U01 MH 60943, K23 MH 01883-01A1, U01 MH60900, K23MH001883, U01MH060903, U01 MH60833, U01MH060900, U01MH060848, U01MH060642, U01 MH 60642, U01 MH60903, U01MH060833, U01MH060943, U01 MH60848)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Keywords
methylphenidate, attention deficit hyperactivity disorder, preschool children, functional outcome, social skills, social competence, classroom behavior, emotional state, parental stress, parent and teacher ratings, depression, dysthymia, Parenting Stress Index
MeSH terms
Affect, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child Behavior, Child, Preschool, Data Interpretation, Statistical, Double-Blind Method, Emotions, Female, Humans, Male, Methylphenidate, Parents, Schools, Social Behavior, Stress, Psychological, Treatment Outcome

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