Cited by 229Diabetes Management and ResearchDiabetes Management and EducationDiabetes Treatment and Management

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Real-World Performance of the MiniMed™ 780G System: First Report of Outcomes from 4120 Users

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Silva, Julien Da, Lepore, Giuseppe, Battelino, Tadej, Arrieta, Arcelia, Castañeda, Javier, Grossman, Benyamin, Shin, John, Cohen, Ohad·2022·Diabetes Technology & Therapeutics

DOI 10.1089/dia.2021.0203PMC PMC8817690

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Abstract

Background: The MiniMed™ 780G system includes an advanced hybrid closed loop (AHCL) algorithm that provides both automated basal and correction bolus insulin delivery. The preliminary performance of the system in real-world settings was evaluated. Methods: Data uploaded from August 2020 to March 2021 by individuals living in Belgium, Finland, Italy, the Netherlands, Qatar, South Africa, Sweden, Switzerland, and the United Kingdom were aggregated and retrospectively analyzed to determine the mean glucose management indicator (GMI), percentage of time spent within (TIR), below (TBR), and above (TAR) glycemic ranges, system use, and insulin consumption in users having ≥10 days of sensor glucose (SG) data after initiating AHCL. The impact of initiating AHCL was evaluated in a subgroup of users also having ≥10 days of SG data, before AHCL initiation. Results: Users ( N = 4120) were observed for a mean of 54 ± 32 days. During this time, they spent a mean of 94.1% ± 11.4% of the time in AHCL and achieved a mean GMI of 6.8% ± 0.3%, TIR of 76.2% ± 9.1%, TBR <70 of 2.5% ± 2.1%, and TAR >180 of 21.3% ± 9.4%, after initiating AHCL. There were 77.3% and 79.0% of users who achieved a TIR >70% and a GMI of <7.0%, respectively. Users for whom comparison with pre-AHCL was possible ( N = 812) reduced their GMI by 0.4% ± 0.4% ( P = 0.005) and increased their TIR by 12.1% ± 10.5% ( P < 0.0001), post-AHCL initiation. More users achieved the glycemic treatment goals of GMI <7.0% (37.6% vs. 75.2%, P < 0.0001) and TIR >70% (34.6% vs. 74.9%, P < 0.0001) when compared with pre-AHCL initiation. Conclusion: Most MiniMed 780G system users achieved TIR >70% and GMI <7%, while minimizing hypoglycemia, in a real-world condition.

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Method
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Da Silva J, , Arrieta A, , Castaneda J, et al.: Real-world Performance of the MiniMed™ 780G System: impact of initiating automated basal and correction boluses. Diabetes Technol Ther, 2021; 23:A79–A80.
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Authors: Silva, J. D., Lepore, G., Battelino, T., Arrieta, A., Castañeda, J., Grossman, B., Shin, J., & Cohen, O.
Affiliations: Medtronic (Switzerland) (CH)
Ospedale Papa Giovanni XXIII (IT)
University of Ljubljana (SI)
Medtronic (Netherlands) (NL)
Medtronic, Northridge, California, USA.
Medtronic (United States) (US)
Corresponding author: Cohen, Ohad
ORCID: Lepore, Giuseppe
Battelino, Tadej
Arrieta, Arcelia
Castañeda, Javier
Shin, John
Cohen, Ohad
Venue: Diabetes Technology & Therapeutics
Publisher: SAGE Publications
Published: 2022-01-31
Volume: 24
Issue: 2
Pages: 113-119
ISSN: 1520-9156 (ISSN-L)
1557-8593
DOI: 10.1089/dia.2021.0203
PMC: PMC8817690
OpenAlex: W3201039184
Cited by: 229
References: 26
Citations by year: 2026: 29 · 2025: 35 · 2024: 61 · 2023: 67 · 2022: 36
FWCI: 30.80
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Diabetes Technology & Therapeutics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: MiniMed 780G, hybrid closed-loop insulin delivery, type 1 diabetes, real-world performance, glucose management indicator, time in range, glycemic control, continuous glucose monitoring
MeSH terms: Blood Glucose, Diabetes Mellitus, Type 1, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Retrospective Studies, Blood Glucose Self-Monitoring

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Real-World Performance of the MiniMed™ 780G System: First Report of Outcomes from 4120 Users

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