The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini.
Open accessAbstract
Episialin is a mucin-type glycoprotein present at the luminal side of most glandular epithelial cells. We have isolated cDNA clones encoding episialin and determined the structure of the gene. The gene encodes a transmembrane protein which consists of, for the greater part, tandem repeats of 20 amino acids. The number of these repeats varies between 40 and 90 among different alleles. The repeats and most of the remainder of the protein are very rich in potential O-linked glycosylation sites. Two different splice variants were found. Interestingly, the proteins encoded by these two variants differ in their signal sequences and in the extreme amino-terminal parts of the mature proteins, suggesting alternative processing of these two species.
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Cited by
The gastrointestinal mucus system in health and disease
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Metadata
- Authors
- Ligtenberg, M. J., Vos, H. L., Gennissen, A. M., & Hilkens, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-04
- Volume
- 265
- Issue
- 10
- Pages
- 5573-5578
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2156087814
- Cited by
- 369
- References
- 19
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. https://app.cochat.ai/papers/10.1016/s0021-9258(19)39399-8
- The paper
- Ligtenberg, M. J., Vos, H. L., Gennissen, A. M., & Hilkens, J. (1990). Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)39399-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
