Antioxidant, mutagenic, and antimutagenic activity of frozen fruits
Abstract
Many studies have focused on the effect of fresh fruits on the risk of developing cancer and other diseases involved with reactive species and free radicals. The intake of frozen fruits has spread widely in the last years, but, until now, their biological activity is not completely known. In this study, 23 samples of frozen fruits were analyzed for their nutritional composition, total polyphenols, total carotenoids, and vitamin C content. Antioxidant, mutagenic, and antimutagenic effects were also evaluated. Antioxidant assays included 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(.)) scavenging activity and determination of superoxide dismutase (SOD)- and catalase (CAT)-like activities. Mutagenic and antimutagenic evaluations were performed in eukaryotic cells of Saccharomyces cerevisiae yeast. Most samples (74%) showed antioxidant activity similar to vitamin C in the DPPH(.) assay, and this activity was positively correlated (r = 0.366; P <or= .01) with carotenoid contents. All samples showed CAT-like activity. SOD-like activity was detected in 56% of samples assayed. Only four fruits (acai, cashew apple, kiwi fruit, and strawberry) showed mutagenic activity when tested in high (5%, 10%, and 15% [wt/vol]) concentrations. Twelve samples presented antimutagenic effects against hydrogen peroxide, and this effect was positively correlated with CAT-like activity (r = 0.400; P
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Phenols exhibit antiviral effects.
“In addition to anticancer effects, the phenols exhibited anti-inflammatory activity, antiviral effects, and inhibited the human platelet aggregation [156,157,158,159,160].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [156]
Phenols inhibit human platelet aggregation.
“In addition to anticancer effects, the phenols exhibited anti-inflammatory activity, antiviral effects, and inhibited the human platelet aggregation [156,157,158,159,160].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [156]
Phenols exhibit anti-inflammatory activity.
“In addition to anticancer effects, the phenols exhibited anti-inflammatory activity, antiviral effects, and inhibited the human platelet aggregation [156,157,158,159,160].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [156]
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
- Authors
- Spada, P. D. S., de Souza, G. G. N., Bortolini, G. V., Henriques, J. A. P., & Salvador, M.
- Affiliations
- Universidade de Caxias do Sul (BR)
- Instituto de Biotecnologia, Universidade de Caxias do Sul, Caxias do Sul, Brazil
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2008-03
- Volume
- 11
- Issue
- 1
- Pages
- 144-151
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W2091076453
- Cited by
- 89
- References
- 52
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 11 · 2012: 10
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
- Keywords
- frozen fruit, antioxidant activity, mutagenicity, antimutagenic activity, total polyphenols, carotenoids, vitamin C, superoxide dismutase-like activity, catalase-like activity, DPPH radical scavenging, Saccharomyces cerevisiae, hydrogen peroxide, reactive oxygen species, açaí, cashew apple, kiwifruit, strawberry
- MeSH terms
- Antioxidants, Ascorbic Acid, Biphenyl Compounds, Carotenoids, Catalase, Flavonoids, Food Handling, Freezing, Fruit, Mutagenicity Tests, Mutagens, Pesticides, Phenols, Picrates, Saccharomyces cerevisiae, Superoxide Dismutase, Antimutagenic Agents, Polyphenols
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