Dietary cinnamon supplementation and changes in systolic blood pressure in subjects with type 2 diabetes
Abstract
Experimental and some clinical evidence suggests that ingestion of cinnamon may improve metabolic measures in individuals with diabetes; however, few human studies have been designed to examine this association as their primary objective. In this study adult subjects 30 years of age or older with type 2 diabetes were randomized to treatment with 1,200 mg/day cinnamon or matched placebo. Blood pressure, hemoglobin A1c, fasting blood glucose, lipid profile, physical examination, and blood and urine chemistry were measured at baseline and at the 12-week follow-up end-of-treatment visit. In total, 59 subjects (40.7% female; mean age, 63.05±10.85 years) were recruited. Systolic blood pressure (SBP) declined from baseline values by 3.4±11.4 mm Hg in the cinnamon group and increased by 1.9±10.2 mm Hg in the placebo group (P=.06). In repeated-measures analysis, a significant by-treatment difference over time was detected (P=.02). However, when baseline SBP was included in the model as a covariate, change from baseline SBP was no longer associated with treatment. Although cinnamon added to the diets of spontaneously hypertensive rats has been shown to decrease SBP in a dose-dependent manner, results of the present study in humans suggest that the by-treatment difference in change-from-baseline SBP was a function of regression to the mean rather than a treatment-associated change.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Results from 6 RCTs did not find a difference in blood glucose or insulin levels after cinnamon consumption.
“Results from 6 RCTs did not find a difference in blood glucose or insulin levels after cinnamon consumption [368,377,378,379,380,381,382].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [380]
Cites
Cinnamon improves glucose and lipids of people with type 2 diabetes
Khan, A., Safdar, M., Ali Khan, M. M., Khattak, K. N., & Anderson, R. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3215 · Cited by 981 · see citing works
Peng, X., Cheng, K., Ma, J., Chen, B., Ho, C., Lo, C., Chen, F., & Wang, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073065v · Cited by 263 · see citing works
Manrique, C. M., Lastra, G., Gardner, M., & Sowers, J. R. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.014 · Cited by 224 · see citing works
Sheng, X., Zhang, Y., Gong, Z., Huang, C., & Zang, Y. Q. (2008) · PPAR Research · doi:10.1155/2008/581348 · Cited by 203 · see citing works
Talpur, N. A., Echard, B. W., Ingram, C., Bagchi, D., & Preuss, H. G. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00386.x · Cited by 103 · see citing works
Preuss, H. G., Echard, B. W., Polansky, M. M., & Anderson, R. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719525 · Cited by 97 · see citing works
Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension
Zhou, M.-S., Schulman, I. H., & Raij, L. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01096.2008 · Cited by 60 · see citing works
Functional foods for health: Focus on diabetes
Rudkowska, I. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.01.011 · Cited by 58 · see citing works
Cinnamon Supplementation in Patients with Type 2 Diabetes Mellitus
Pham, A. Q., Kourlas, H., & Pham, D. Q. (2007) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.27.4.595 · Cited by 56 · see citing works
Brands, M. W., Bell, T. D., Rodriquez, N. A., Polavarapu, P., & Panteleyev, D. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90528.2008 · Cited by 18 · see citing works
Insulin resistance and associated dysfunction of resistance vessels and arterial hypertension.
Busija, D. W., Miller, A. W., Katakam, P. V. G., et al. (2005) · PubMed · Cited by 16 · see citing works
Alpert, M., Govindarajan, G., Rosario, M. L. D., & Reisin, E. (2009) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.00035.x · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis
Allen, R. W., Schwartzman, E., Baker, W. L., Coleman, C. I., & Phung, O. J. (2013) · The Annals of Family Medicine · doi:10.1370/afm.1517 · Cited by 269 · see citing works
Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199 · see citing works
Mousavi, S. M., Rahmani, J., Kord-Varkaneh, H., Sheikhi, A., Larijani, B., & Esmaillzadeh, A. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2019.02.017 · Cited by 69 · see citing works
- Authors
- Wainstein, J., Stern, N., Heller, S., & Boaz, M.
- Affiliations
- Wolfson Medical Center (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Tel Aviv University (IL)
- Corresponding author
- Boaz, Mona
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2011-12
- Volume
- 14
- Issue
- 12
- Pages
- 1505-1510
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W2024465772
- Cited by
- 50
- References
- 12
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- cinnamon, type 2 diabetes, systolic blood pressure, dietary supplementation, regression to the mean, HbA1c, fasting blood glucose, lipid profile, spontaneously hypertensive rats
- MeSH terms
- Administration, Oral, Aged, Blood Pressure, Cinnamomum zeylanicum, Diabetes Mellitus, Type 2, Diet, Female, Follow-Up Studies, Glycated Hemoglobin, Humans, Hypertension, Hypoglycemic Agents, Male, Middle Aged, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
