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Review: Oxidative Stress and Disease
Abstract
This communication briefly reviews aspects of oxidative stress and disease, particularly maturity onset cataract. The review considers a number of issues such as why lens and cataract research is important, what is oxidative stress, its relationship to disease and how does a tissue defend itself against such stress. Three diseases (chronic lung disease, diabetes and Alzheimer's disease) in which oxidative stress has differing roles are briefly discussed. The impact of oxidative stress upon the development of maturity onset cataract is considered and approaches are delineated which will establish the importance of such stress.
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“With aging, a decreased performance of cell endogenous antioxidant system occurs; thus, elderly people are more susceptible to oxidative stress [2, 3].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [2]
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Metadata
- Authors
- SPECTOR, A.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- SPECTOR, ABRAHAM
- Venue
- Journal of Ocular Pharmacology and Therapeutics
- Publisher
- SAGE Publications
- Published
- 2000-04
- Volume
- 16
- Issue
- 2
- Pages
- 193-201
- ISSN
- 1080-7683 (ISSN-L)
- 1557-7732
- OpenAlex
- W2090028564
- Cited by
- 244
- References
- 25
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 14 · 2013: 12 · 2012: 13
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ocular Pharmacology and Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- oxidative stress, lens, cataract, chronic lung disease, diabetes mellitus, Alzheimer's disease, antioxidant defense, pathogenesis
- MeSH terms
- Animals, Cataract, Humans, Lens, Crystalline, Reactive Oxygen Species, Oxidative Stress
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