The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Sex and Racial Differences in Pharmacological Response: Where Is the Evidence? Pharmacogenetics, Pharmacokinetics, and Pharmacodynamics
Abstract
The Food and Drug Administration (FDA) reviewed 300 new drug applications between 1995 and 2000. Of the 163 that included a sex analysis, 11 drugs showed a >40% difference in pharmacokinetics between males and females, which was listed on the product label, yet no dosing recommendations were made based on sex. Female sex has been shown to be a risk factor for clinically relevant adverse drug reactions. Would simply dosing females based on their different pharmacokinetics decrease the incidence of adverse events? The answer is not known. Sex-dependent pharmacodynamic effects have been identified. The role of pharmacokinetics vs. pharmacodynamics is unclear, as is the impact of pharmacogenetics on both. This review highlights a few specific examples in each area in which sex differences in pharmacokinetics and pharmacodynamics are important and provides recommendations for additional needed research.
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Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes
Waxman, D. J., & Holloway, M. G. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056705 · Cited by 815
Sex and gender differences in health: Science & Society Series on Sex and Science
Regitz‐Zagrosek, V. (2012) · The EMBO Reports · doi:10.1038/embor.2012.87 · Cited by 572
Growth Hormone Regulation of Sex-Dependent Liver Gene Expression
Waxman, D. J., & O’Connor, C. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0007 · Cited by 458
Gender differences in drug responses
FRANCONI, F., BRUNELLESCHI, S., STEARDO, L., & CUOMO, V (2007) · Pharmacological Research · doi:10.1016/j.phrs.2006.11.001 · Cited by 454
Högberg, J., Hanberg, A., Berglund, M., Skerfving, S., Remberger, M., Calafat, A. M., Filipsson, A. F., Jansson, B., Johansson, N., Appelgren, M., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10788 · Cited by 413
Metadata
- Authors
- Anderson, G. D.
- Venue
- Journal of Women's Health
- Publisher
- SAGE Publications
- Published
- 2005-01
- Volume
- 14
- Issue
- 1
- Pages
- 19-29
- ISSN
- 1059-7115 (ISSN-L)
- 1540-9996
- 1931-843X
- OpenAlex
- W1968825227
- Cited by
- 321
- References
- 93
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Anderson, G. D. (2005). Sex and Racial Differences in Pharmacological Response: Where Is the Evidence? Pharmacogenetics, Pharmacokinetics, and Pharmacodynamics. Journal of Women's Health. https://doi.org/10.1089/jwh.2005.14.19
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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