The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Lymphatic Function and Immune Regulation in Health and Disease
Open accessAbstract
L ymphatic vessels are present throughout the body, except in the central nervous system and bone marrow.The lymph nodes (LNs), spleen, and other secondary lymphoid organs (e.g., Peyer's patches) are strategically located in anatomical sites where they collect foreign antigen and antigen presenting cells to activate antigen-specific lymphocytes efficiently. 1 In the peripheral tissues, specialized lymphatic capillaries-called initial lymphatic vessels-allow soluble materials and cells to enter the lymphatic system easily.The collected fluid and cells form lymph, which is transported by smooth muscle-invested collecting lymphatic vessels to the draining lymph node.The lymph node provides a highly organized microarchitecture that supports optimal immune surveillance.The ''filtered'' lymph fluid, as well as naı ¨ve and activated lymphocytes, exit the lymph node via efferent lymphatic vessels.Lymphatic capillaries, collecting lymphatic vessels, and lymph nodes together provide protective immunity for the body.Disruptions of lymphatic function compromise immune function and result in lymphedema.In this review, we will summarize the current knowledge of how lymphatic function is altered in inflammatory states, cancer, and infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In the lymph node, lymph can be concentrated or diluted (12) by the exchange of fluid through high endothelial venules (HEVs), which are located in the lymph node paracortical cortex, and have a specialized endothelium that facilitates fluid exchange and diapedesis of lymphocytes (84).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [84]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
Molecular regulation of vessel maturation
Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,594
A Randomized Comparison of Sentinel-Node Biopsy with Routine Axillary Dissection in Breast Cancer
Veronesi, U., Paganelli, G., Viale, G., Luini, A., Zurrida, S., Galimberti, V. E., Intra, M., Veronesi, P., Robertson, C., Maisonneuve, P., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa012782 · Cited by 2,204
Sentinel-Node Biopsy or Nodal Observation in Melanoma
Morton, D. L., Thompson, J. F., Cochran, A. J., Mozzillo, N., Elashoff, R. M., Essner, R., Nieweg, O. E., Roses, D. F., Hoekstra, H. J., Karakousis, C. P., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060992 · Cited by 1,817
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,720
The role of myeloid cells in the promotion of tumour angiogenesis
Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2444 · Cited by 1,642
Lymphangiogenesis: Molecular Mechanisms and Future Promise
Tammela, T., & Alitalo, K. K. (2010) · Cell · doi:10.1016/j.cell.2010.01.045 · Cited by 1,485
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357
Lymphangiogenesis in development and human disease
Alitalo, K. K., Tammela, T., & Petrova, T. V. (2005) · Nature · doi:10.1038/nature04480 · Cited by 1,287
The role of nitric oxide in tumour progression
Fukumura, D., Kashiwagi, S., & Jain, R. K. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1910 · Cited by 1,279
Flagged first, then by citations
Research works printed but not linked: 7
- 10.1002/jemt.1163.abs · DOI
- Johnston MG, 1983, J Pharmacol Exp Ther, 226, 603
- Anderson AO, 1975, Am J Pathol, 80, 387
- Anderson AO, 1976, Immunology, 31, 731
- Mebius RE, 1990, Immunology, 71, 423
- Golshan M, 2006, J Support Oncol, 4, 381
- Paavonen K., 2002, J Rheumatol, 29, 39
Cited by
Sorted by citations
Items 101–122 of 122
Adjah, J., Musimbi, Z. D., Mugo, R. M., Midha, A., Hartmann, S., & Rausch, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1483274 · Cited by 1
Recurrent hypoxemia: When crackles crack the case
Gardner, K. J., Sumner, J., Lu, M., Moschovis, P. P., Sagar, P., O'Sullivan, B., & Nelson, B. A. (2021) · Pediatric Pulmonology · doi:10.1002/ppul.25419 · Cited by 1
The immune system in lymphedema and lymphangitis of the lower limbs
Vilas, M. M. (2016) · Revista Cubana de Angiología y Cirugía Vascular
Korth, M. (2017) · OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University) · doi:10.18725/oparu-4364
Defining Novel Mechanisms in Cardiovascular Development
Plein, A. (2015) · UCL Discovery (University College London)
Askarifirouzjaei, H., Khajoueinejad, L., Fazeli, M., Tiraihi, T., & Pourfathollah, A. A. (2019) · doi:10.21203/rs.2.17302/v1
KAPHA W.S.R. TO MUCUS GLANDS SECRETION AND LYMPHATIC SYSTEM
Shukla, M., Sharma, R. K., & Sharma, D. (2021) · International Ayurvedic Medical Journal · doi:10.46607/iamj1309022021
Machado, H., & Niz, M. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.10.536298
A 6-day-old Newborn with Sudden Severe Respiratory Distress
Vanderhorst, E. R., Avendano, R. D., Javier, M. C., & Patil, U. P. (2024) · NeoReviews · doi:10.1542/neo.25-3-e216
Lymphatic System and Immune Cell-Based Response
Umeyor, C. E., Patil, A. B., Ezewudo, E., Bairagi, G., Anure, A., & Patravale, V. B. (2024) · Springer eBooks · doi:10.1007/978-3-031-64828-1_20
Reactive Changes in Lymph Node Structure in Peritonitis and during Treatment with a New Antibiotic
Абдрешов, С. Н., Демченко, Г. А., Горчаков, В. Н., Yessenova, M. A., & Yeshmukhanbet, A. N. (2024) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-024-06269-8
A review on vascularized breast reconstruction
Tawil, B. J., & Jigisha, H. (2025) · Journal of Stem Cell Research & Therapeutics · doi:10.15406/jsrt.2025.10.00207
Lymphatic Complications in Patients Undergoing Melanoma Surgery in Peru
Ku, G. D. L. C., Farzan, J. J., Guart, J. A., Desai, A., Franco-Mesa, C., Mroueh, J., Mroueh, V., Briskin, C., Kulkarni, N., Rodríguez, O., et al. (2026) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000007375
Benchmarking niche identification via domain segmentation for spatial transcriptomics dataPreprint
Wang, Y., Chen, Y., Yang, L., Wang, C., Cai, J., & Xin, H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.27.708202 · Cited by 1
Nanoformulation d'une molécule antirétrovirale pour le ciblage des réservoirs du VIH-1
Quaillet, M. (2018) · theses.fr (ABES) · doi:10.70675/bf2ed959z99f4z4d77zbb0ez1bd1d150b365
CXCL12/CXCR4 in embryonic lymphatic vasculature and lymph node formation
Shayan, R. R. (2019) · theses.fr (ABES) · doi:10.70675/ff79b97dz9f23z4461z9722z3927a9faf1f5
Browne, F., Fernando, A. R., Boast, A., Osowicki, J., & WILKS, D. J. (2026) · Australasian Journal of Plastic Surgery · doi:10.34239/ajops.162871
Keane, K., & Castorena‐Gonzalez, J. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.04.742795
Further Insights Into the Mechanisms of Lymph Node Metastasis
Nathanson, D. S., O’Melia, M. J., Rosso, K. C. F., Wood, I. S., Lall, D., & Bui, J. T. (2026) · Cancer Medicine · doi:10.1002/cam4.72404
Innate immune potential of primary lymphatic endothelial cells
Berendam, S. J. (2015) · D-Scholarship@Pitt (University of Pittsburgh)
Metadata
- Authors
- Liao, S., & Padera, T. P.
- Affiliations
- National Institutes of Health (US)
- Venue
- Lymphatic Research and Biology
- Publisher
- SAGE Publications
- Published
- 2013-09
- Volume
- 11
- Issue
- 3
- Pages
- 136-143
- ISSN
- 1539-6851 (ISSN-L)
- 1557-8585
- PMC
- PMC3780287
- OpenAlex
- W2013073123
- Cited by
- 122
- References
- 116
- Citations by year
- 2026: 7 · 2025: 23 · 2024: 13 · 2023: 15 · 2022: 6 · 2021: 12 · 2020: 8 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 3
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lymphatic Research and Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1dp2od008780-01)
- National Heart, Lung, and Blood Institute (K99HL111343)
- National Cancer Institute (R00CA137167)
- National Institute of Allergy and Infectious Diseases (R21AI097745)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015903)
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- lymphatic system, lymphatic vessels, lymph nodes, secondary lymphoid organs, immune regulation, lymphedema, lymphatic dysfunction, inflammation, cancer, infection, immune surveillance, lymphatic capillaries, collecting lymphatic vessels
- MeSH terms
- Animals, Humans, Immune System, Lymphatic Diseases, Lymphatic Metastasis, Lymphatic System, Models, Biological, Lymphangiogenesis, Lymphatic Vessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
