Cited by 157Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAutomotive and Human Injury Biomechanics

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Adaptation of the Fluid Percussion Injury Model to the Mouse

CARBONELL, W. SHAWN, MARIS, DONALD O., McCALL, TODD, GRADY, M. SEAN·1998·Journal of Neurotrauma

DOI 10.1089/neu.1998.15.217

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Abstract

Fluid percussion injury (FPI) is a well-characterized experimental model of traumatic brain injury (TBI) in the rat. Many pathophysiologic consequences and mechanisms of recovery after TBI rely on neurochemical pathways that can be examined in genetically altered mice. Therefore, FPI applied to mice may be a useful experimental tool to investigate TBI at the molecular level. In the present study, we establish FPI as a viable model of TBI in the mouse by characterizing acute neurological, histopathological, and behavioral changes. Right-sided parasagittal FPI or sham treatment was administered in male C57BL/6 mice. Acute neurological evaluation revealed righting reflexes in the injured animals (p < 0.001). Deficits in spatial learning and memory were observed in the Morris water maze (MWM) 5 and 6 days after injury. A novel MWM data analysis protocol is described. The injured group (n = 18) demonstrated impaired performance in the MWM during acquisition (p < 0.05) and probe trials (p < 0.025) compared to sham animals (n = 16). At 7 days postinjury, glial fibrillary acidic protein immunohistochemistry revealed intense cortical, callosal, and hippocampal gliosis. The modified Gallyas silver degeneration stain consistently labeled cell bodies and terminals throughout the ipsilateral cortex, axons in the gray matter-white matter interface above the corpus callosum and within the corpus callosum bilaterally, and terminals and fibers in the thalamus bilaterally. Additionally, the mo…

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BackgroundResult
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“Amongst the 44 injured animals, the average pressure pulse was 2.226 ± 0.013 atm and the average righting time was 384 ± 12 seconds, which correspond to a moderate injury (Morehead et al., 1994; Schmidt and Grady, 1995; Carbonell et al., 1998; Hallam et al., 2004).”
BackgroundInfluential

Authors: CARBONELL, W. S., MARIS, D. O., McCALL, T., & GRADY, M. S.
Affiliations: University of Washington (US)
ORCID: CARBONELL, W. SHAWN
Venue: Journal of Neurotrauma
Publisher: SAGE Publications
Published: 1998-03
Volume: 15
Issue: 3
Pages: 217-229
ISSN: 0897-7151 (ISSN-L)
1557-9042
DOI: 10.1089/neu.1998.15.217
OpenAlex: W1978835755
Cited by: 157
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 10 · 2017: 10 · 2016: 13 · 2015: 5 · 2014: 9 · 2013: 11 · 2012: 4
FWCI: 1.89
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Journal of Neurotrauma (publishedVersion)
PubMed (publishedVersion)
Funders: University of Washington
National Institutes of Health (5p50ns030305-05, 5r01ns033107-03)
National Institute of Neurological Disorders and Stroke (NS-30305, NS33107)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
Keywords: fluid percussion injury, traumatic brain injury, mouse model, spatial learning and memory, Morris water maze, gliosis, glial fibrillary acidic protein, corpus callosum, thalamus, righting reflex, behavioral deficits
MeSH terms: Animals, Brain Injuries, Postural Balance, Glial Fibrillary Acidic Protein, Gliosis, Male, Mice, Inbred C57BL, Neuroglia, Neurons, Silver Staining, Maze Learning, Mice, Rats

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Adaptation of the Fluid Percussion Injury Model to the Mouse

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